Observatory of the Lille Paediatric Allergy Unit

Condition(s) studied

Investigational drug(s) / intervention(s)

Oral immunotherapy: Clinical Follow up

Study summary

The goal of this study is to set up a paediatric observatory within the allergology department of The saint Vincent Hospital, Lille. The study aims to:

• Collect exhaustive prospective data from patients eligible for oral immunotherapy.

This prospective observatory will enable statistical analyses to be carried out on common food allergens such as hazelnut, cashew nut, pistachio and others.

Eligibility

Primary outcome measure(s)

• Age — at inclusion
  For each patient, and for each visit during the treatment period the collection of anthropometric, sociodemographic and medical data relating to oral food challenge will be done
• Sex — at inclusion
  For each patient, and for each visit during the treatment period the collection of anthropometric, sociodemographic and medical data relating to oral food challenge will be done
• Oral immunotherapies followed before inclusion — at inclusion
  For each patient, and for each visit during the treatment period the collection of anthropometric, sociodemographic and medical data relating to oral food challenge will be done
• Determination of comorbidities — at inclusion
  For each patient, and for each visit during the treatment period the collection of anthropometric, sociodemographic and medical data relating to oral food challenge will be done
• Determination of allergen under consideration — at inclusion
  For each patient, and for each visit during the treatment period the collection of anthropometric, sociodemographic and medical data relating to oral food challenge will be done
• Specific IgE — at inclusion
  For each patient, and for each visit during the treatment period the collection of anthropometric, sociodemographic and medical data relating to oral food challenge will be done
• Recombinants — 5 years
  For each patient, and for each visit during the treatment period the collection of anthropometric, sociodemographic and medical data relating to oral food challenge will be done
• Cumulative ingested dose — 5 years
  This dose will be determined by mg/food and m/ food protein
• Allergic reaction according to the Astier and Coll classification — 5 years
  Astier score for anaphylaxis according to symptoms: 0- Absent 1- Abdominal pain spontaneous resolution, Urticaria \< 10 papules, Eczema, Rhinoconjunctivitis 2-1 Organ affected, Abdominal pain requiring treatment, Angioedema with laryngeal involvement, Moderate asthma: cough and PEF \> 20%. 3- 2 Affected organs 4- 3 organs affected or Asthma attack requiring treatment or Laryngeal edema or Arterial hypotension 5- Cardiorespiratory impairment requiring ICU admission
• Type of oral challenge — 5 years
  Type of ingested food during the oral immunotherapy: fresh food / industrial products
• Reception of emergency kit — 5 years
  If the reception of an emergency kit was needed will be determined by yes/no
• Second oral food challenge — 5 years
  If a second oral challenge was needed will be determined by yes/no
• Tolerance according to reactogenic thresholds for allergens — 5 years
  Subsequent visits will follow the patient's usual routine until the desensitisation threshold is reached or the patient decides to stop the oral immunotherapy protocol.
• Amount of reactions IgE mediated — 5 years
  Subsequent visits will follow the patient's usual routine until the desensitisation threshold is reached or the patient decides to stop the oral immunotherapy protocol.
• Amount of reactions non IgE mediated — 5 years
  Subsequent visits will follow the patient's usual routine until the desensitisation threshold is reached or the patient decides to stop the oral immunotherapy protocol.

Trial sites (1)

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