Echocardiography and MRI: Analysis of echocardiography and MRI parameters
Study summary
Degenerative mitral insufficiency secondary to valve prolapse is the most common valve disease in Western countries. In the absence of specific treatment, it spontaneously progresses to heart failure and death when it is severe. Surgical mitral valve repair (or mitral plastic surgery) is the preferred treatment for primary mitral insufficiency by prolapse in case of severe leakage if associated with clinical and/or echocardiographic markers of poor prognosis (i.e., with high risk of morbi-mortality during their follow-up).
It is therefore essential to refine the risk stratification of these patients in order to identify at-risk patients who should potentially benefit earlier from invasive care (cardiac surgery), or conversely, close monitoring.
A number of echocardiographic and MRI parameters may have been associated with a poorer prognosis.
A cohort of patients with primary mitral insufficiency (MI) will be followed to study the relationships of a set of factors to patient prognosis.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Any patient with primary mitral insufficiency by prolapse (any grade) diagnosed by Trans-Thoracic Echocardiography (TTE)
* From November 2010 to April 2019 (retrospective cohort)
* From May 2019 to May 2024 (prospective cohort)
* No previous surgery of the mitral valve before the first ultrasound
* Adults
* Patient who has been informed and not opposed to the use of his or her medical record data
Exclusion Criteria:
* Secondary MI
* Primary MI without valve prolapse
* Active endocarditis
* Patient's refusal to participate in the study
* Patient under guardianship or curatorship
Primary outcome measure(s)
Time before the first morbi-mortality event — 10 years The impact of different parameters obtained by Doppler echocardiography (two-dimensional or three-dimensional mode) or MRI on the prognosis of time of the first morbi-mortality event arrival will be studied.
Morbi-mortality is defined as the occurrence of at least one of the following events during follow-up:
* Death from any cause
* Cardiovascular death defined as linked to heart failure, myocardial infarction, arrhythmia episode and sudden death
* Hospitalization for heart failure
* Occurrence of atrial fibrillation
* Occurrence of a stroke
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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