SchizophreniaTranscranial Magnetic StimulationHallucinations, Verbal Auditory
Investigational drug(s) / intervention(s)
The rTMS methodThe cTBS method
The rTMS method: The patient receives treatment under naturalistic conditions in routine practice.
The cTBS method: The patient receives the treatment under naturalistic conditions in routine practice.
Study summary
This open naturalistic study aims to evaluate the efficacy of rTMS in routine practice on auditory resistant hallucinations (AHR) of patients with schizophrenia. To this end, two stimulation methods will be offered to patients: the rTMS stimulation method and the cTBS stimulation method.We principally use the AHRS scale to evaluate the effectiveness of rTMS on RAH in patients with schizophrenia. Our main hypothesis is that rTMS used under naturalistic conditions, in addition to antipsychotics, would allow a relative improvement of resistant auditory hallucinations assessed by the AHRS scale between baseline and end of treatment in patients with schizophrenia.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patient over 18 years of age
* Patient diagnosed with schizophrenia according to DSM-V criteria (Diagnostic and Statistical Manual of Mental Disorder V5, 2013)
* Presence of auditory hallucinations: Resistant auditory hallucinations: resistance to treatment with 2 different well-conducted antipsychotics.
* Patient agreeing to participate in the study and having signed an informed consent
* Patient with French language skills
* Affiliation to a social security system
* Women of childbearing age must be on contraception and have a negative pregnancy test (βHCG)
Exclusion Criteria:
* Have a contraindication to MST: intracranial foreign body, unstabilized epilepsy, cochlear implant
* Presence of an unstabilized medical condition
* Pregnant woman (Women of childbearing age without effective contraception)
* Current or less than one month old engagement in another research protocol
* A person who is subject to a safeguard of justice measure
* An adult under curatorship
* Minor patients with mental health problems
* Pregnant or breastfeeding women
* A person in a social fragility (Persons deprived of liberty by a judicial or administrative decision, hospitalized persons)
* Persons incapable or unable to give consent
Primary outcome measure(s)
The evolution will be evaluated mainly with the AHRS (Auditory Hallucinations Rating Scale) — Baseline and at the end of the treatment, also at 1 month and 3 months after the end of the treatment Refer to the definition of AHRS above (in Primary Outcome Measure)
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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