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Clinical Trials in France / NCT06506734
Recruiting Observational

Dental Dyschromia and Quality of Life in Early Prolonged Hyperbilirubinemia

NCT06506734 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Toulouse
Phase
Observational
Started
2026-04-07
Last updated
2026-05-12

Condition(s) studied

Dental Diseases

Investigational drug(s) / intervention(s)

Questionnaires

Questionnaires: * " Psychosocial Impact of Dental Aesthetics Questionnaire " PMID 24280547 * " Orofacial Esthetic Scale " PMID 30856637 * " Orofacial Esthetic Scale " PMID 34231057 * A photograph of the patient's smile will be sent to 2 dentists who will also assess the presence or absence of dental dyschromia.

Study summary

The main objective of this study is to assess the prevalence of dental discoloration (dental dyschromia) in children who experienced high levels of bilirubin in their blood (hyperbilirubinemia) during their early years. The study will also examine risk factors associated with this condition, such as the duration and severity of hyperbilirubinemia, underlying diseases, and treatments received.

The researchers hypothesize that the quality of life of individuals with dental dyschromia is lower than that of individuals without dyschromia. The results of this study will be used to discuss coverage for dental care with health insurance for children affected by this condition.

Eligibility

Sex
ALL
Min age
12 Years
Max age
18 Years
Healthy volunteers
No
Inclusion Criteria: * A patient with biliary atresia, progressive familial intrahepatic cholestasis, or Alagille syndrome * Patient or legal representative not opposed to participating in this research. Exclusion Criteria: * Inability to understand and respond to quality of life questionnaires

Primary outcome measure(s)

  • Prevalence of dental dyschromia — from birth to study completion, a maximum of 19 years
    presence of dyschromia or not evaluated by 2 investigators

Trial sites (9)

FacilityCityRegionStatus
University Hospital Bordeaux Bordeaux France Recruiting
University Hosptial Caen Caen France Recruiting
University Hospital Lille Lille France Recruiting
Hospices Civils de Lyon Lyon France Recruiting
University Hospital Marseille Marseille France Recruiting
Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, FHU Hépatinov Paris France Recruiting
Assistance Publique-Hôpitaux de Paris, Hôpital Bretonneau, Paris Paris France Recruiting
Assistance Publique-Hôpitaux de Paris, Hôpital Necker Paris France Recruiting
University Hospital Rennes Rennes France Recruiting

More University Hospital, Toulouse trials in France

Intragastric Balloon in Obese Patients With Uncontrolled Asthma Recruiting
Study of the Interprofessional Reproducibility of a Clinical Observation Scale for the Development of Very Premature Infants Starting soon
Avacopan Added to Standard-of-care Therapy in ANCA-associated Vasculitis With Severe Kidney Involvement Starting soon
LUng and Cardiac Ultrasound for REspiratory Distress in ElDerly Recruiting
Semantic Rehabilitation for Patients With Primary Progressive Semantic Aphasia Recruiting

Other trials for the same condition

Music During Dental Children Care Under MEOPA Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06506734 on ClinicalTrials.gov ↗ ← All trials in France