Endometriosis Transcriptomic Cell Atlas

NCT06502548 · tracked via the Priya Life Science France tracker

Sponsor

University Hospital, Toulouse

Phase

Not applicable

Started

2024-09-27

Last updated

2025-04-10

Condition(s) studied

EndometriosisInfertility

Investigational drug(s) / intervention(s)

EndometriosisTubal ligation or Hysterectomy

Endometriosis: Anatomopathology waste will be recovered, i.e. the remainder of the endometriosis lesions and the remainder of the endometrial biopsy. A blood sample will be taken the day before surgery, as part of the treatment, for a hormonal check-up.

Tubal ligation or Hysterectomy: During surgery, an endometrial biopsy will be taken for research purposes. A blood sample will be taken the day before surgery, as part of the treatment, for a hormonal check-up.

Study summary

Endometriosis is an estrogen-dependent, chronic inflammatory gynecologic disease affecting women of reproductive age, with a therapeutic wandering of 6 to 10 years. A better understanding of the initiation phase is a major challenge to improve diagnosis and treatment. The most widely accepted hypothesis to explain the formation of endometriotic lesions is the tubal retrograde reflux during menstruation. However, only 10% of the reproductive age women will develop endometriosis while 90% of women experience retrograde menstruation. This raises the question of the stem cells present in the endometrium and menstrual reflux of these patients, but also of both the peritoneal microenvironment and the estrogenic local signaling which allow the implantation of these lesions.

Eligibility

Sex

FEMALE

Min age

18 Years

Max age

45 Years

Healthy volunteers

Inclusion Criteria: * Patients over 18 and under 45 years of age * Patients with multiple endometriosis sites (superficial, deep and endometriomas) with an indication for surgery to treat disabling painful symptoms and stage III or IV endometriosis in the context of infertility. * Healthy patients including those operated on between the ages of 18 and 45 for tubal ligation * Healthy patients operated on between the ages of 18 and 45 for hysterectomies for benign causes other than endometriosis or adenomyosis * Patients operated on strictly at the time of menstruation * Participants who have not been on hormonal treatment for 2 months * Participant having signed the free and informed consent form * Membership of a Social Security scheme or equivalent Exclusion Criteria: * Patients with endometriosis non-surgically treated * Patients with endometriosis receiving hormonal treatment at the time of surgery or having received hormonal treatment in the 2 months prior to surgery * Patients with adenomyosis only * Healthy non-endometriotic patients undergoing hysterectomy for infectious or malignant causes * Patients benefiting from a legal protection measure (guardianship, curatorship, safeguard of justice) * Patients with positive serology for human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B (HBV) and hepatitis C (HCV)

Primary outcome measure(s)

Analyze of the number of the different cell types (immune cells and endometrial stem cells) present in the endometrium of healthy control patients — During surgery
Analyze of the number of the different cell types (immune cells and endometrial stem cells) present in the peritoneal fluid of healthy control patients — During surgery
Analyze of the number of the different cell types (immune cells and endometrial stem cells) present in endometriosis lesions for endometriosis patients. — During surgery
Analyze of the number of the different cell types (immune cells and endometrial stem cells) present in endometrium of endometriosis patients. — During surgery

Trial sites (1)

Facility	City	Region	Status
University Hospital Toulouse	Toulouse	France	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06502548 on ClinicalTrials.gov ↗ ← All trials in France