Non-steroidal Anti-inflammatory in Cardiac Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

pain management: o Pain management in both arms Intraoperative time: intravenous ketamine 0.5 mg kg-1, intravenous dexamethasone 8 mg Postoperative time: paracetamol 1 g every 6 hours a day, nefopam 20 every 8 hours a day, patient control analgesia with morphine or oxycontin

ketoprofen: Ketoprofen 100 mg twice a day, during 48 after surgery, intravenous administration

PLacebo: Placebo twice a day, during 48 h after surgery, intravenous administration

Study summary

Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.

Eligibility

Primary outcome measure(s)

• reduction in pain intensity during chest physiotherapy at 24 hours from the end of surgery — at 24 hours
  Pain intensity will be assessed using the NRS at 24 hours from the end of surgery during chest physiotherapy
• NSAIDs reduce postoperative at rest at 24 hours from the end of surgery — at 24 hours
  Pain intensity will be assessed at rest at 24 hours from the end surgery using the numerous rating scale (NRS) graded from 1 (no pain) to 10 (high pain intensity)

Trial sites (1)

More Centre Hospitalier Universitaire, Amiens trials in France

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