Understanding the Mechanisms of Autism : an MRI and Social Cognition Study

NCT06334588 · tracked via the Priya Life Science France tracker

Sponsor

Assistance Publique - Hôpitaux de Paris

Phase

Not applicable

Started

2024-04-17

Last updated

2025-12-23

Condition(s) studied

Autism Spectrum Disorder

Investigational drug(s) / intervention(s)

MRIEye-trackingClinical ScalesResearch of genetic anomalies

MRI: Anatomical and functional images will be acquired and review by an experienced neuro-radiologist

Eye-tracking: Eye movements and follow a person's gaze will be recorded during visualization of stimuli presented in the screen by analyzing images of the eye captured by an infrared camera

Clinical Scales: CGI, E-CAR and ABC will be used for behavior and clinical evaluation

Research of genetic anomalies: For the diagnosis of autism, patients benefit from a a genetic assessment. This is carried out as part of their care

Study summary

The main goal of this study is to investigate anatomo-functional brain abnormalities associated with autism spectrum disorders using a multimodal brain imaging approach, as well as its links to social cognition difficulties measured using eye-tracking

Eligibility

Sex

ALL

Min age

3 Months

Max age

28 Years

Healthy volunteers

Accepted

Inclusion Criteria: For subjects diagnosed with ASD or suspected of ASD : * 3 months ≤ age \< 25 years ; * an MRI required as part of the clinical procedures * written consent obtained from parents or legal guardians. * Affiliated to social security For Healthy control subjects over 3 years of age: * between 3 and 28 years of age * no known neurological or psychiatric pathology * written consent obtained from parents or legal guardian. * Affiliated to social security For Healthy control subjects under 5 years of age: * age between 3 months and 5 years * who have had an MRI scan in the pediatric radiology department at Necker Hospital, which was found to be normal. * with no known neurological or psychiatric pathology * no opposition from legal representative Exclusion Criteria: * Contraindication to MRI (pacemaker, intracorporeal metallic body, claustrophobia). * Impossibility for healthy volunteers to remain still during MRI

Primary outcome measure(s)

Rest cerebral blood flow (CBF) — at inclusion
Whole brain rest CBF measured with Arterial spin labelling MRI

Trial sites (1)

Facility	City	Region	Status
Hôpital Necker Enfants Malades	Paris	France	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06334588 on ClinicalTrials.gov ↗ ← All trials in France