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Clinical Trials in France / NCT06300788
Recruiting Not applicable

Inorganic Pyrophosphate Homeostasis (PPi) in Pediatric Chronic Kidney Disease

NCT06300788 · tracked via the Priya Life Science France tracker
Sponsor
Centre Hospitalier Universitaire de Nice
Phase
Not applicable
Started
2024-05-27
Last updated
2026-07-27

Condition(s) studied

Pyrophosphate, Fetuin A, IL1, IL6, TNFalpha, Control

Investigational drug(s) / intervention(s)

PPI and T50 dosing

PPI and T50 dosing: Sampling for PPI determination and T50 in blood and urine.

Study summary

The investigator aim to identify the role of inorganic pyrophosphate and other anti-calcifying molecules in vascular disease in children with chronic kidney disease, with a view to developing therapeutic approaches aimed at limiting the onset of vasculopathy.

Eligibility

Sex
ALL
Min age
0 Years
Max age
18 Years
Healthy volunteers
No
Inclusion Criteria: All groups : * Minor patients (\<18 years) * Patients of both sexes * Informed patients and parents who have signed the informed consent form * Patients affiliated to social security Control group : \- Patients with no particular pathology undergoing surgery and receiving a preoperative check-up CKD groups : * Patients on dialysis for more than 3 months, regardless of technique * Kidney transplant patients * Patients with CKD, whatever the cause Exclusion Criteria: * Progressive cancer or kidney disease * Treatments that may modify PPi concentration (e.g. bisphosphonates)

Primary outcome measure(s)

  • Plasma pyrophosphate concentration [PPi]pl in children with CKD — 18 months
    Compare plasma pyrophosphate concentration \[PPi\]pl between children with CKD (dialysis group and non-dialysis, non-transplant group) and \[PPi\]pl of children with normal renal function. Plasma PPi concentration during fasting sampling; (μmol/L) by a proprietary assay developed at LP2M. We will match the 3 MRC groups with their respective control groups according to age, sex and pubertal stage.

Trial sites (1)

FacilityCityRegionStatus
CHU Nice - Hôpital de l'Archet 2 Nice Alpes-Maritimes Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06300788 on ClinicalTrials.gov ↗ ← All trials in France