Clinical Trials in France / NCT06284382
Recruiting
Not applicable
Interaction Between Early Trauma and Odor-induced Dopamine Release
NCT06284382 · tracked via the Priya Life Science France tracker
Condition(s) studied
Trauma, Psychological
Investigational drug(s) / intervention(s)
High score at Childhood Trauma Questionnaire.Low score at Childhood Trauma Questionnaire.
High score at Childhood Trauma Questionnaire.: In the "presence of early trauma" arm, 15 participants are recruited based on a high Childhood Trauma Questionnaire total score.
Low score at Childhood Trauma Questionnaire.: In the "absence of early trauma" arm, 15 participants are recruited based on a low Childhood Trauma Questionnaire total score.
Study summary
This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.
Eligibility
Inclusion Criteria:
* Aged 18 years or older
* Have been selected based on the Childhood Trauma Questionnaire score
* Non-smoker
* Be able to speak and read French
* Sign a consent form before intervention.
Exclusion Criteria:
* A pre-existing condition that affects olfaction including congenital anosmia, upper respiratory tract infection, nasal and/or sinus disease,
* Be on medication, with the exception of oral contraceptives
* Pregnant or breast-feeding woman (check with urine pregnancy tests);
* Contraindications to TMS or MRI (implanted medical devices or metallic foreign body in the head);
* Psychiatric disorders
* Use of psychotropic drugs
* Have participated in a study involving the injection of a radiotracer during the year
Primary outcome measure(s)
- Dopamine transmission measured with positron emission tomography — 24 months
Subcortical dopaminergic transmission will be analyzed, using \[11C\]raclopride PET activity (D2 receptor antagonist)
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| CH le Vinatier | Bron | France | Recruiting |
More Hôpital le Vinatier trials in France
Other trials for the same condition
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06284382 on ClinicalTrials.gov ↗ ← All trials in France