Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
Clinical Trials in France / NCT06241924
Recruiting Not applicable

Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement

NCT06241924 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Bordeaux
Phase
Not applicable
Started
2024-02-05
Last updated
2025-07-23

Condition(s) studied

Parkinson DiseaseEpilepsy

Investigational drug(s) / intervention(s)

High Resolution Electroencephalogram (EEG-HR)Stereo-electro-encephalography (SEEG)

High Resolution Electroencephalogram (EEG-HR): Local field potentials (LFP) recording using EEG-HR

Stereo-electro-encephalography (SEEG): Local field potentials (LFP) recording using sEEG

Study summary

The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range.

The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion criteria : * Male or Female * Between 18 and 75 years of age * With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device. * Giving free, informed, written consent signed by the participant and the investigator Or * With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG * With at least one electrode exploring the basal ganglia or the thalamus. * Able to perform the simple motor task * Affiliated or beneficiary of a social security scheme; * Giving free, informed, written consent signed by the participant and the investigator Exclusion criteria: * Be incapable of giving consent personally * Be subject to a legal protection measure or be placed under judicial protection; * Being pregnant or breastfeeding * Present a serious and/or decompensated somatic or psychiatric illness

Primary outcome measure(s)

  • difference in the cortico-subcortical electrophysiological coherence value — Day 1
    difference in the cortico-subcortical electrophysiological coherence value between normal movement (control condition) and hypo- or hyperkinetic pathological movement

Trial sites (1)

FacilityCityRegionStatus
CHU de Bordeaux Bordeaux France Recruiting

More University Hospital, Bordeaux trials in France

Validation of a Digitalised Intraoral Protection Recruiting
Mitochondrial Disease-associated ImmunoDeficiencies Recruiting
ESCAPE : Evaluation of Spinal Conservation by Endoscopic Procedures to Avoid Fusion Recruiting
Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre Recruiting
COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial Recruiting

Other trials for the same condition

Clinical Evaluation of A neW Management Strategy for Patients With pArKinson's disEase usiNg an Innovative telemonitorING (AWAKENING) Starting soon
Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease Active, not recruiting
Early Biomarkers of Neurodegeneration in Parkinsonian Syndromes Starting soon
Evaluation of the Risk of Cognitive Deficit After Surgery of Epilepsy by Dynamic Spectral Imaging (ISD) of the Cognitive Functions in Patients Explored in StereoElectroEncephaloGraphy (SEEG) Recruiting
Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06241924 on ClinicalTrials.gov ↗ ← All trials in France