Digestive endoscopy: Digestive endoscopies are performed in the operative room under general anaesthetic 3 months after the introduction or change of treatment. Biopsies of the upper, middle and lower thirds of the esophagus will be taken and analyzed for pathology.
Study summary
The investigator would like to create a prospective cohort of patients in order to describe eosinophilic esophagitis with the specificities corresponding to our geographical territory, and to study their evolution at 3 months, 6 months, 12 months, 18 months and 24 months.
This study would also enable us to investigate the quality of life of these chronically ill patients
Eligibility
Sex
ALL
Min age
2 Years
Max age
17 Years
Healthy volunteers
No
Inclusion Criteria:
* Diagnosis of OE according to the diagnostic criteria of the PNDS published in July 2022
* Due to start treatment.
* informed consent from one of the 2 parents or the representative of parental authority.
* Membership of a social security scheme.
Exclusion Criteria:
\-
Primary outcome measure(s)
Determine the rate of complete remission — at 3 months, 6 months, 12 months, 18 months and 24 months from treatment initiation. Complete remission will be defined according to the following criteria:
1. Abolition of clinical symptoms as assessed by the Pediatric Eosinophilic Esophagitis Symptom Score
2. Endoscopic score: EoE Endoscopic Reference Score (EREFS) ≤ 2 in the lower, middle and upper thirds of the esophagus.
3. Eosinophilic infiltrate \< 5/HPF in standard HES (Haemato-Eosin-Safran) stain on biopsies from lower, middle and upper thirds of esophagus
4. No therapeutic change at follow-up visit to assess remission
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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