Risk Markers of Arterial Aging. The Paris Prospective Study III-2

Condition(s) studied

Investigational drug(s) / intervention(s)

high-precision carotid echo-tracking: evaluation of vascular aging parameters and baroreflex sensitivity

Study summary

The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.

Eligibility

Primary outcome measure(s)

• carotid diameter — by 2027
  high precision carotid echo tracking diameter in mm
• intima media thickness — by 2027
  high precision echo tracking intima media thickness of the common carotid artery in mm
• carotid plaques — by 2027
  high precision carotid echo tracking carotid plaques
• wall cross sectional area — by 2027
  high precision carotid echo tracking carotid wall cross sectional area, mm2
• distensibility coefficient — by 2027
  high precision carotid echo tracking distensibility coefficient in 10-3/kPa
• elastic modulus — by 2027
  high precision carotid echo tracking Young's elastic modulus, 10-3\*kPa
• pulse wave velocity — by 2027
  high precision carotid echotracking pulse wave velocity, m/s
• carotid wall stress — by 2027
  high precision carotid echotracking circumferential wall stress in kPa
• stiffness — by 2027
  high precision carotid echotracking Beta stiffness index
• pulse pressure — by 2027
  high precision carotid echotracking pulse pressure in mmHg

Trial sites (1)

More Institut National de la Santé Et de la Recherche Médicale, France trials in France

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