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Clinical Trials in France / NCT05961488
Recruiting Not applicable

Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest

NCT05961488 · tracked via the Priya Life Science France tracker
Sponsor
CHU de Reims
Phase
Not applicable
Started
2024-03-04
Last updated
2024-03-06

Condition(s) studied

Out of Hospital Cardiac Arrest Without ST-segment Elevation

Investigational drug(s) / intervention(s)

Coronary Calcium Score and Coronary CT angiogram

Coronary Calcium Score and Coronary CT angiogram: Introduction of early Coronary CT angiogram and Coronary Calcium Score in the first days after a resuscitated out-of-hospital cardiac arrest.

Study summary

Out-of-hospital cardiac arrest (OHCA) has multiple etiologies. In the absence of ST-elevation myocardial infarction, percutaneous coronary intervention (PCI) is delayed. This study aims to determine the diagnostic accuracy of Coronary Calcium Score (CCS) and Coronary CT Angiogram (CCTA) to rule out a coronary artery disease (CAD) in the first days after an OHCA.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion criteria : * Patients hospitalized in intensive care unit after a resuscitated out-of-hospital cardiac arrest * No obvious cause for sudden death on anamnestic information, CT brain and CT pulmonary angiogram. * Absence of ST elevation myocardial infarction Non-inclusion criteria : * In-hospital cardiac arrest * Refractory cardiac arrest * Indication of immediate coronary angiography * ST-elevation myocardial infarction or unknown left bundle branch block * Dynamic or presumably new contiguous ST/T-segment changes * Cardiogenic shock * Life-threatening arrhythmias * Coronary artery bypass graft * Pregnancy * Multiple organ failure syndrome * Know severe chronic kidney disease (GFR \<30mL/min/1,73m²) Exclusion criteria : * During the Coronary computerized tomographic angiogram : * Haemodynamic instability requiring high dose of vasopressors (\>1µg/kg/min of Norepinephrine) * Non sinusal cardiac rhythm * KDIGO 1 Acute kidney injury

Primary outcome measure(s)

  • Diagnostic accuracy of Coronary Computerized Tomographic Angiogram to rule-out a coronary stenosis > 50% — During hospitalization (maximum 7 days from ICU admission)

Trial sites (1)

FacilityCityRegionStatus
Damien JOLLY Reims France Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05961488 on ClinicalTrials.gov ↗ ← All trials in France