Starting soon
Observational
Prognostic Role of High Sensitivity Troponin During Follow up in the Evolution of Acute Myocarditis
Condition(s) studied
Myocarditis
Study summary
The goal of this observational study is to observe if ultra-sensitive troponins (us) measurement between 3 and 6 months after the acute event will be sensitive enough to dispense with all other examinations, particularly cardiac magnetic resonance imaging (MRI), in patients suffering from myocarditis.
The investigators will collect patient events by telephone, once a year for 4 years.
Eligibility
Inclusion Criteria:
* Male or female patients over 18 years of age
* Patients hospitalized at Grenoble Alpes University Hospital and Lyon University Hospital between June 2016 and June 2025
* Having presented chest pain and ≥1 diagnostic criteria or if no chest pain, presence of ≥2 diagnostic criteria below :
* Electrical abnormalities (supra- or sub-ST, T-wave inversion, atrioventricular blocks 1-3 conduction disorders)
* Elevation of cardiac biomarkers (troponin)
* Kinetic abnormalities on cardiac ultrasound
* Associated with ≥2 MRI criteria of tissue abnormality (edema, hyperhemia, myocardial fibrosis)
* Patient affiliated to a social security scheme or beneficiary of such a scheme
* No opposition to participation
Exclusion Criteria:
* Absence of documented coronary artery disease (cardiac CT or coronary angiography) or age \<30 and low risk of coronary artery disease.
* Myocarditis secondary to immunotherapy.
* Presence of documented coronary artery disease (coronary angiography or cardiac CT)
* Presence of cardiomyopathy (hypertrophic cardiomyopathy, dilated cardiomyopathy)
* Infiltrative heart disease (sarcoidosis or cardiac amyloidosis)
* Severe valve disease
* Takotsubo
* Constrictive or chronic pericarditis
* Loeffler's endocarditis
* Non-compaction of the left ventricle
* Cardiac tumor
* Pulmonary embolism
* Coronary spasm
* Patients covered by articles L1121-5 to L1121-8 of the French Public Health Code (pregnant women, parturients, nursing mothers; persons deprived of liberty by judicial or administrative decision; protected adults)
Primary outcome measure(s)
- Major Adverse Cardiac Events (MACE) rate at 4 years — 4 years
MACE being defined by a composite criterion: 1) all-cause mortality, 2) cardiac decompensation requiring readmission, 3) cardiac transplantation,4) documented sustained ventricular arrhythmias \>30s, 5) recurrence of myocarditis.
Trial sites (1)
| Facility | City | Region | Status |
| Grenoble University Hospital |
La Tronche |
France |
|
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