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Clinical Trials in France / NCT05929144
Recruiting Not applicable

Optimization of MRI Sequences Used in the Study of Neurodegenerative Diseases

NCT05929144 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Caen
Phase
Not applicable
Started
2023-05-05
Last updated
2023-07-03

Condition(s) studied

Memory Disorders

Investigational drug(s) / intervention(s)

MRI sequences testing

MRI sequences testing: Testing different MRI sequences in order to optimize them

Study summary

The Inserm NeuroPresage team has been using MRI for more than 20 years in the study of normal ageing and memory pathologies to further the understanding and the characterization of early diagnosis and the cerebral substrates of cognitive deficits in patients, particularly in the context of neurodegenerative diseases.

Two years ago, a new 3T MRI camera was installed at the Cyceron centre. It is more efficient and should make it possible to obtain better quality images and/or to reduce the time required to acquire these images.

In this context, it seems important to test the different sequences that we classically use in our studies, or that we plan to implement in our next studies (learning and text retrieval fMRI task), in order to optimize them, with a view to integrating them in our future studies.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * Healthy volunteers of legal age * Affiliation with a social security scheme or beneficiary of such a scheme * Signing of the protocol informed consent * For women of childbearing age or capacity, a urine pregnancy test before inclusion Exclusion Criteria: * Protected persons in accordance with articles L. 1121-5 to L.1121-8 of the Public Health Code: protected adults, pregnant and nursing women * Presence of contraindications to MRI examination without contrast agents injection * Presence of a chronic neurological or psychiatric condition (including substance use disorder) * History of brain disease (vascular, degenerative, malformative, tumour, or head trauma with loss of consciousness for more than one hour) * Current or recent use of medications that may interfere with imaging (psychotropic drugs, antihistamines with anticholinergic action, antiparkinsonian drugs, benzodiazepines including muscle relaxants, long-term steroidal anti-inflammatory drugs, antiepileptic drugs, central painkillers)

Primary outcome measure(s)

  • Optimization of MRI sequences — During MRI sessions
    TR, TE, Flip Angle, asset phase, asset slice parameters

Trial sites (1)

FacilityCityRegionStatus
GIP Cyceron Caen France Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05929144 on ClinicalTrials.gov ↗ ← All trials in France