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Clinical Trials in France / NCT05838235
Recruiting Not applicable

Adapted Physical Activity Program (APA) for Effort Rehabilitation of Children and Teenagers With Marfan Syndrome

NCT05838235 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Toulouse
Phase
Not applicable
Started
2023-04-24
Last updated
2026-03-03

Condition(s) studied

Marfan Syndrome

Investigational drug(s) / intervention(s)

Adapted Physical Activity program

Adapted Physical Activity program: The Adaptated Physical Activity program will consist of a Personalized Training Program

Study summary

This research study aims to evaluate the effect of a 6-month adapted physical activity program (APA) on the endurance capacities (evaluated as the maximum oxygen consumption \[VO2 peak\] on a cardiopulmonary exercise test) of children and adolescents with Marfan syndrome or related.

Eligibility

Sex
ALL
Min age
7 Years
Max age
17 Years
Healthy volunteers
No
Inclusion Criteria: * Genetically confirmed Marfan syndrome or related syndrome * Girl or boy aged 7 to 17 * Informed and written consent signed by at least one of the two holders of parental authority * Patient affiliated to a social security scheme or equivalent Exclusion Criteria: * Cardiac contraindications to the APA program: * Severe aortic dilation (aortic diameter \> 45 mm) * and/or left ventricular failure (left ventricular ejection fraction \<45%) * and/or severe mitral leakage ≥ grade 3 * Pregnancy

Primary outcome measure(s)

  • Measurement of maximum endurance — At baseline
    maximum oxygen consumption (VO2 peak) during a cardiopulmonary exercise test will be measured
  • Measurement of maximum endurance — Up to 6 month
    maximum oxygen consumption (VO2 peak) during a cardiopulmonary exercise test will be measured

Trial sites (1)

FacilityCityRegionStatus
CHU Toulouse Toulouse France Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05838235 on ClinicalTrials.gov ↗ ← All trials in France