Cardiovascular and Venous Thromboembolism Disease in Patients with Von Willebrand Disease in the French West

NCT05773638 · tracked via the Priya Life Science France tracker

Sponsor

University Hospital, Brest

Phase

Observational

Started

2021-12-26

Last updated

2025-02-06

Condition(s) studied

Von Willebrand Diseases

Study summary

Due to increasing of life expectancy, patients with von Willebrand disease are exposed to age-related pathologies such as cancer or cardiovascular diseases. Management of thrombotic events is challenging given the inherent bleeding risk in von Willebrand disease. Few data are currently available in the literature.

The aim of the study is to describe the frequency and nature of arterial and venous thromboembolic events and atrial fibrillation in patients with von Willebrand disease in the West of France.

The investigators will perform a retrospective multicenter study conducted in the von Willebrand population of the French West. Von Willebrand adult patients followed in one of the French West medical centers participating in the study, who presented deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, acute coronary syndrome, acute limb ischemia, atrial fibrillation, arteriopathy of the lower limbs, angina will be eligible.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Von Willebrand disease * Adult * Followed-up in a reference center of West of France (Caen, Brest, Nantes, Rennes, Le Mans, Angers) * Consented to be included in BERHLINGO database * Have presented a thrombotic and/or embolic event or cardiovascular disease including deep vein thrombosis, pulmonary embolism, ischemic stroke, transient ischemic attack, acute coronary syndrome, acute limb ischemia or angina or obliterating arteriopathy of the lower limbs, atrial fibrillation. * Have not expressed their opposition Exclusion Criteria: * \- Expression of opposition * Acquired von Willebrand syndrome * Patients under legal protection * Minor

Primary outcome measure(s)

To describe the frequency of arterial and venous thromboembolic events and cardiac arrhythmia due to atrial fibrillation in patients with Willebrand disease in the Greater West. — 12 months
Occurrence of a thromboembolic event validated by an adjudication committee
To describe the nature of arterial and venous thromboembolic events and cardiac arrhythmia due to atrial fibrillation in patients with Willebrand disease in the Greater West. — 12 months
Occurrence of a thromboembolic event validated by an adjudication committee

Trial sites (6)

Facility	City	Region	Status
CHU d'Angers	Angers	France	Not Yet Recruiting
CHU de Brest	Brest	France	Recruiting
CHU de Caen	Caen	France	Not Yet Recruiting
CH le MANS	Le Mans	France	Not Yet Recruiting
CHU de Nantes	Nantes	France	Not Yet Recruiting
CHU de Rennes	Rennes	France	Not Yet Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05773638 on ClinicalTrials.gov ↗ ← All trials in France