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Clinical Trials in France / NCT05641142
Recruiting Not applicable

Prospective Study of Antiplatelet and Anticoagulation Therapy in Hereditary Haemorrhagic Telangiectasia

NCT05641142 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Clermont-Ferrand
Phase
Not applicable
Started
2023-04-07
Last updated
2026-07-10

Condition(s) studied

Hereditary Hemorrhagic TelangiectasiaRendu Osler Disease

Investigational drug(s) / intervention(s)

monitoring the use of anticoagulant and/or antiplatelet therapy in patients with osler rendering disease

monitoring the use of anticoagulant and/or antiplatelet therapy in patients with osler rendering disease: Monitoring: * hemoglobin and ferritin levels * transfusion or intravenous iron * hospitalization for bleeding or thrombose * digestive bleeding and/or another haemorrhagic accident * severity of epistaxis * quality of life

Study summary

The goal of this clinical trial is to evaluate in real life, in patients with Hereditary Hemorrhagic Telangiectasia (HHT), the tolerance of the strategy of use of anticoagulant and/or antiplatelet, by comparing a new exposure period (first trimester of treatment) to a period of reference non-exposure (last trimester before start of treatment).

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patient with Rendu-Osler disease with an indication of antiplatelet and/or anticoagulant introduced for less than 3 months (inclusion period within 3 months of exposure) * Age \> 18 years old * Patient able to understand and agree to participate in the study * Affiliation to a social security system Exclusion Criteria: * Patient with an indication of antiplatelet and/or anticoagulant but for whom treatment has not been introduced or introduced for more than 3 months * Refusal to participate * Pregnant woman or who are breast feeding * Patients under maintenance of justice, wardship or legal guardianship

Primary outcome measure(s)

  • Number of transfusions and/or intravenous iron — 3 months after exposure to anticoagulants and/or antiplatelet
    Number of transfusions and/or intravenous iron before (3 months) and within 3 months after exposure to anticoagulants and/or antiplatelet in patients with Rendu-Osler disease.

Trial sites (18)

FacilityCityRegionStatus
CHU d'Angers Angers France Recruiting
CHU de Bordeaux Bordeaux France Recruiting
Hôpital Ambroise Paré Boulogne-Billancourt France Not Yet Recruiting
CHU de Caen Normandie Caen France Recruiting
CHU clermont-ferrand Clermont-Ferrand France Recruiting
CHU de Dijon Dijon France Recruiting
CHRU de Lille Lille France Not Yet Recruiting
Hospices Civiles de Lyon Lyon France Recruiting
Assistance Publique - Hôpitaux de Marseille Marseille France Not Yet Recruiting
CHU de Montpellier Montpellier France Recruiting
CHU de Nancy Nancy France Recruiting
CHU de Nantes Nantes France Recruiting
CHU de Nice Nice France Recruiting
AP-HP - Hôpital Ténon Paris France Recruiting
CHU de Poitiers Poitiers France Not Yet Recruiting
CHU de Rennes Rennes France Recruiting
CHRU de Strasbourg Strasbourg France Recruiting
CHU de Toulouse Toulouse France Not Yet Recruiting

More University Hospital, Clermont-Ferrand trials in France

Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding Recruiting
Health and Exercise Response in Children With Chronic and Auto-immune Pathologies Recruiting
Sarcopenic Obesity: Estimation of Prevalence and Identification of Clinical and Biological Determinants in a Cohort of Adult Obese Patients and Longitudinal Follow-up Starting soon
BEnefit of HYpnosis on Pain During Stitches in Emergency Room Recruiting
Preservation of Women's Fertility: Evaluation of Innovative Methods for Ovarian Tissue Cryopreservation Active, not recruiting

Other trials for the same condition

A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT) Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05641142 on ClinicalTrials.gov ↗ ← All trials in France