Feasibility of Ethanolization of Vein of Marshall With Specific Catheter in Atrial Fibrillation Ablation
Condition(s) studied
Investigational drug(s) / intervention(s)
Marshall ethanolisation: Destruction of Marshall bundles by ethanol 96% infusion (3 separate injections of 3.3ml)
Study summary
In patients with persistent AF (PsAF), ablation limited to pulmonary vein (PV) isolation is the most straightforward approach, but results only in 50% of arrhythmia freedom at 1 year follow-up. Substrate modification strategies have failed to demonstrate their superiority with variable reported success rate. The Marshall network is a highly arrhythmogenic structure that has not been systematically targeted so far, probably because of the absence of dedicated tools to make its ablation simple and easy. We sought to investigate the use of a specific catheter for visualization and ethanolization of vein of Marshall allowing to systematically include this target in the ablation set.
The main objective of this study is to demonstrate the feasibility to use the Targeted Endovascular Delivery (TED) catheter specifically for visualization and ethanolization of vein of Marshall.
Eligibility
Primary outcome measure(s)
- Acute success rate of the procedure — 12 months
Success rate complete realization of ethanolization procedure
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| CHU de Bordeaux | Pessac | France | Recruiting |
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05427435 on ClinicalTrials.gov ↗ ← All trials in France