Role of Glucose Metabolism in Migration of Cutaneous Dendritic Cells in Psoriasis

Condition(s) studied

Investigational drug(s) / intervention(s)

Biopsy and venous blood: A skin biopsy will be performed under local anesthesia in diabetic and non-diabetic psoriatic patients (25 per group) in the injured area (joint extension) and in the non-injured area more than 2 cm from any lesion in the same area. In patients in the diabetic or non-diabetic control group (25 per group) only one biopsy will be performed. Peripheral venous blood will be collected in heparin tubes for metabolic parameter analysis and blood CD analysis

Study summary

Dendritic cells (DC) paly a key role in the induction and chronicity of psoriasis by capturing the antigenes and activating the T cell repsonse. This activation requires their migration from the cutaneous sensitisation site to the lymph nodes. This migration requires an important intracellular metabolic activity, with a strong involvmenet of glucdic metabolism. This activity is linked with the systemic activity. This study aims to compare the migration and the phenotypic and metabolic caracteristics of blood and skin DCs in patients with or without psoriasis and with or without type 2 diabetes,

Eligibility

Primary outcome measure(s)

• Percentage of dentridic cells producers of IL-23 — at baseline
  Alterations in the percentage of dentridic cells that have migrated with the metabolic status of patients

Trial sites (1)

More Centre Hospitalier Universitaire de Nice trials in France

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