Detection of Significant Coronary Artery Disease by Promising Biomarker: A2A Adenosine Receptor (A2AR) Assays

Inclusion Criteria: * Man or woman aged ≥18 and \<90 years old; * Must not be of child-bearing potential (≥1 year post-menopausal, contraceptive, or surgically sterile); * Symptoms suggestive of CCS and intermediate PTP (15-85%) according to the Diamond classification (2); * Undergone at least one stress imaging test (annex 3) or an abnormal coronary Computed Tomography Angiography (CTA) with the recommendation to perform ICA with FFR in all intermediate lesions; * Non-contributive ECG (resting 18-lead); * Normal echocardiography with left ventricular ejection fraction (LVEF) \>50%; * Cardiac troponin level \<99th percentile; * Intended for an invasive strategy for CCS; * Affiliated to or beneficiary of, a social security system; * Signed written informed consent. Exclusion Criteria: Persons referred in articles L.1121-5 to L.1121-8 and L.1122-2 of the Public Health Code: * Pregnant, parturient or breastfeeding woman * Person deprived of liberty for judicial or administrative decision * Person under psychiatric care * Minor person (non-emancipated) * History of CAD or known CAD * Suspected acute coronary syndrome (ACS: annex 4) * Inability to undergo adenosine testing * Allergy to iodinated contrast media * Bleeding diathesis * Known significant bleeding risk according to physician judgment * Severe hepatic failure (ASAT, ALAT\>3ULN) * Ischemic stroke within 1 month or a history of hemorrhagic stroke * Bradycardia * Platelet count \<100 G/L * Hemoglobin \<10g/dl * Major surgery or trauma within 10 days * Life expectancy \<1 year * Pre-test Probability \<15% or \>85% * History and clinical examination suggesting non-cardiac chest pain * Contraindication to coronary angiography * Thyroid disorder * Refusal to participate