Respiratory Muscles and Work of Breathing in Children

Condition(s) studied

Investigational drug(s) / intervention(s)

Esogastric pressure measurement: Measurement of work of breathing and respiratory muscles strength using an esogastric catheter. One measurement or before and after (6 months and 1 year) the initiation of a pharmacological treatment in order to assess the effect of the treatment on respiratory muscle function.

Study summary

Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology of respiratory impairment and guide therapeutic management. The use of an invasive technique (esogastric probe) makes it possible to specifically explore the diaphragm, the accessory inspiratory muscles and the expiratory muscles in order to detect dysfunction or paralysis of these muscles, and to estimate the work of breathing in order to better guide the respiratory management.

The primary objective of the study is to evaluate the respiratory effort in children with primary or secondary impairment of the respiratory muscles during spontaneous breathing or during mechanical ventilation.

Eligibility

Primary outcome measure(s)

• Esophageal pressure-time product (PTPoes) — Day 0
  The integral of the esophageal pressure signal over inspiratory time
• Diaphragmatic pressure-time product (PTPdi) — Day 0
  The integral of the transdiaphragmatic pressure signal over inspiratory time
• Work of breathing (WOB) — Day 0
  Total work of breathing (WOBt) is calculated (in Joules/L) as the area under the pressure-volume curve, using the Campbell diagram. Elastic (WOBe) and resistive (WOBr) are estimated as the 2/3 and 1/3 of WOBt value, respectively.

Trial sites (1)

More Assistance Publique - Hôpitaux de Paris trials in France

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