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Clinical Trials in France / NCT04971564
Recruiting Observational

Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia

NCT04971564 · tracked via the Priya Life Science France tracker
Phase
Observational
Started
2024-03-19
Last updated
2026-01-22

Condition(s) studied

Cerebral HypoxiaIschemic Stroke

Investigational drug(s) / intervention(s)

Blood sampling

Blood sampling: Blood sampling will be made to Day 0, Day 3 and to 3 month after inclusion

Study summary

The goal of this trial is to study, in three well-defined clinical situations responsible for cerebral hypoxia, the concentrations of biomarkers of thrombo-inflammation compared to a population of patients without cerebral hypoxia, and to study in patients with cerebral hypoxia the association between these concentrations and the clinical evolution.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: \- For cases, admitted within the first 36 hours of an acute neurological symptom related to : * An ischaemic cerebrovascular accident (iCVA) eligible for a mechanical thrombectomy procedure, * A subarachnoid haemorrhage (SAH, all aetiologies) : patient presenting with at least a modified Fisher scale 3 or 4, * An intra-parenchymal haematoma (IPH) with greatest axis ≥ 20mm or with NIHSS on admission \>4. OR * For control patients, admitted within 7 days of the onset of acute neurological symptomatology related to a clinical diagnosis of transient ischaemic attack (TIA) - based on thorough questioning of the patient on admission - and prior to imaging, with an ABCD2≥ 2 score. * Express consent to participate in the study. * Member or beneficiary of a social security. Exclusion Criteria: * Pre-existing functional and/or cognitive disability * Patient under legal protection. * Pregnant or breastfeeding woman. * Patient with secondary haemorrhagic transformation. Secondary exclusion criteria : * Patients with an ischaemic lesion visible on imaging, unrelated to large vessel occlusion and therefore ineligible for mechanical thrombectomy. * Patients diagnosed with an acute non-vascular neurological pathology (migraine, epilepsy, etc.). * TIA patients presenting an abnormality on follow-up imaging 24-48 hours after the initial imaging. Excluded patients will be replaced.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Hôpital Fondation Adolphe de Rothschild Paris Île-de-France Region Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04971564 on ClinicalTrials.gov ↗ ← All trials in France