Blood sampling: Blood sampling will be made to Day 0, Day 3 and to 3 month after inclusion
Study summary
The goal of this trial is to study, in three well-defined clinical situations responsible for cerebral hypoxia, the concentrations of biomarkers of thrombo-inflammation compared to a population of patients without cerebral hypoxia, and to study in patients with cerebral hypoxia the association between these concentrations and the clinical evolution.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
\- For cases, admitted within the first 36 hours of an acute neurological symptom related to :
* An ischaemic cerebrovascular accident (iCVA) eligible for a mechanical thrombectomy procedure,
* A subarachnoid haemorrhage (SAH, all aetiologies) : patient presenting with at least a modified Fisher scale 3 or 4,
* An intra-parenchymal haematoma (IPH) with greatest axis ≥ 20mm or with NIHSS on admission \>4.
OR
* For control patients, admitted within 7 days of the onset of acute neurological symptomatology related to a clinical diagnosis of transient ischaemic attack (TIA) - based on thorough questioning of the patient on admission - and prior to imaging, with an ABCD2≥ 2 score.
* Express consent to participate in the study.
* Member or beneficiary of a social security.
Exclusion Criteria:
* Pre-existing functional and/or cognitive disability
* Patient under legal protection.
* Pregnant or breastfeeding woman.
* Patient with secondary haemorrhagic transformation.
Secondary exclusion criteria :
* Patients with an ischaemic lesion visible on imaging, unrelated to large vessel occlusion and therefore ineligible for mechanical thrombectomy.
* Patients diagnosed with an acute non-vascular neurological pathology (migraine, epilepsy, etc.).
* TIA patients presenting an abnormality on follow-up imaging 24-48 hours after the initial imaging.
Excluded patients will be replaced.
Primary outcome measure(s)
Biomarker rates at day 0 — 24 hours Biomarker: Neutro-Plaket aggregates, extra-cellular DNA networks, von Willebrand Factor
Trial sites (1)
Facility
City
Region
Status
Hôpital Fondation Adolphe de Rothschild
Paris
Île-de-France Region
Recruiting
More Fondation Ophtalmologique Adolphe de Rothschild trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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