Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Patients:
Inclusion criteria
* 18 years and over
* Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
* Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced
Exclusion criteria - Known pregnancy or breastfeeding
Control subjects:
Inclusion criteria
\- 18 years and over
Exclusion criteria
* Wearer of contact lenses
* Topical ocular treatment
* Known pregnancy or breastfeeding
Primary outcome measure(s)
comparison of surface area of cell markers measured on conjunctival epithelial cells, in persons with and without severe eye dryness. — baseline Comparison of the mean surface in patients before treatment for eye dryness versus in persons with no eye dryness. Immunofluorescence analysed in confocal microscopy on conjunctival impression cytology.
Trial sites (1)
Facility
City
Region
Status
Fondation Ophtalmologique A de Rothschild
Paris
France
Recruiting
More Fondation Ophtalmologique Adolphe de Rothschild trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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