rTMS Efficacy Coupled With Mirror Therapy

NCT04867187 · tracked via the Priya Life Science France tracker

Sponsor

Centre Hospitalier Universitaire de Saint Etienne

Phase

Not applicable

Started

2022-10-27

Last updated

2026-05-08

Condition(s) studied

Neuropathic Pain

Investigational drug(s) / intervention(s)

Repetitive transcranial magnetic stimulation (rTMS)Mirror therapy using virtual realityMirror therapy using sham mirror

Repetitive transcranial magnetic stimulation (rTMS): 20 minutes of high frequency (20Hz) rTMS.

Mirror therapy using virtual reality: active mirror-based therapy

Mirror therapy using sham mirror: 20 minutes of sham mirror-based therapy

Study summary

Neuropathic pain is particularly difficult to treat with classic first-line drugs. Neuromodulation techniques using repetitive transcranial magnetic stimulation (rTMS) are useful alternative, but there is a need to improve their analgesic effect.Virtual reality mirror therapy has shown the capacity to alleviate pain and may be easily coupled with rTMS.The present project will investigate in individuals with neuropathic pain the effects of the rTMS coupled with virtual reality mirror therapy.

Eligibility

Sex

ALL

Min age

18 Years

Max age

85 Years

Healthy volunteers

Inclusion Criteria: * Clinical symptoms typical of neuropathic pain * Refractory to drug therapies * Lasting for at least 6 months, with a moderate to severe pain intensity (≥4/10 on Visual Analog Scale, VAS) and a stable pain treatment since 1month at least * Having right to health benefits Exclusion Criteria: * Ferromagnetic components and implanted microprocessors (i.e. cochlear implants) * Drug-resistant or active epilepsy, pacemaker, pregnancy, ongoing depression or personality troubles, and ongoing opioid treatment. * Any other contraindications to MRI scanner (e.g., claustrophobia, etc.).

Primary outcome measure(s)

Pain intensity measurement — Week 9
Averages of the daily visual analogue scale scores (min no pain max pain imaginable) measured during the first week (Week 1) and that measured during the week following the last session (week 9)

Trial sites (2)

Facility	City	Region	Status
Hôpital Neurologique Pierre Wertheimer	Bron	France	Not Yet Recruiting
Centre Hospitalier Universitaire de Saint-Etienne	Saint-Etienne	France	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04867187 on ClinicalTrials.gov ↗ ← All trials in France