This observational study aims to assess the presence of neuropathic pain in children and adolescents who underwent limb amputation during childhood.
The study focuses on two types of neuropathic pain: phantom limb pain and residual limb pain. It also evaluates quality of life and functional autonomy in this population and explores potential associations between neuropathic pain, autonomy, quality of life, and age at amputation.
Using a mixed retrospective and prospective design, data are collected from medical records and standardized questionnaires administered during routine follow-up visits at a specialized pediatric limb anomaly center. The study seeks to improve understanding of neuropathic pain after pediatric amputation and its impact on daily functioning.
Eligibility
Sex
ALL
Min age
5 Years
Max age
18 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients aged between 5 and 18 years (inclusive) (Piaget's concrete operational stage to be able to complete the self-assessment questionnaires)
* Patients who underwent amputation before the age of 15 for girls and 16 for boys (average age of completion of lower limb growth)
* Patients who have not undergone surgery on the amputated limb for at least one year (to avoid bias, as any surgery involving incision can cause temporary neuropathic pain unrelated to the amputation)
* Have obtained the signature of the non-objection form by both parents/legal guardians
* Have obtained the child's consent (verbal consent but recorded)
* Be affiliated with a health insurance plan.
Exclusion Criteria:
* Patients who do not speak French
* Patients whose cognitive abilities are insufficient (as determined by a clinician or reported by parents) to be able to complete self-assessment questionnaires
* Patients undergoing chemotherapy (due to transient neuropathic pain)
* Patients who have received chemotherapy and whose side effects have not yet subsided (on a case-by-case basis depending on the chemotherapy used)
* Patients who have received chemotherapy causing neuropathic pain due to this treatment that has not disappeared.
* Patients placed under protective custody.
Primary outcome measure(s)
Presence of neuropathic pain after pediatric limb amputation — Single assessment at study inclusion (variable time after amputation) Presence of neuropathic pain assessed using the DN4 questionnaire, including phantom limb pain and residual limb pain. A DN4 score of 4 or higher is considered indicative of neuropathic pain.
Trial sites (1)
Facility
City
Region
Status
Hôpitaux Paris Est Val-de-Marne - Centre de Référence des Malformations des Membres
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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