Evolution of Balance and Vestibular Function in Patients Treated With Gammaknife Radiosurgery for Vestibular Schwannoma

Condition(s) studied

Investigational drug(s) / intervention(s)

gammaknife radiosurgery: Patients will undergo questionnaires before the gammaknife radiosurgery, then one year and three years after the intervention.

Study summary

Vestibular schwannomas are benign lesions of the ponto-cerebellar angle that are potentially dangerous because of their growth in a cramped space and the compressive phenomena they can cause. Stereotactic Gammaknife radiosurgery is a treatment option that can be offered for evolutive schwannomas smaller than 2.5-3 cm in size. It allows tumor stabilisation in 85% of cases with less than 1% facial nerve damage risk.

There are controversial results regarding hearing preservation : percentages vary between 25 and 80% in the literature, depending on the criteria used and the post-treatment delay.

Few studies have investigated changes in vestibular function and the impact on balance of radiosurgery, and their results are variable.

These controversial results lead us to comprehensively assess the vestibular function and balance of these patients using a balance-specific quality of life questionnaire, in addition to objective overall vestibular assessments of vestibular function.

Eligibility

Primary outcome measure(s)

• quality of the perceived balance, assessed by the French version of the Dizziness Handicap Inventory (DHI) — before gamma knife radiosurgery (Baseline)
  Questionnaire including 25 items with a "yes/no/maybe" answer possibility
• quality of the perceived balance, assessed by the French version of the Dizziness Handicap Inventory (DHI) — One year after gamma knife radiosurgery
  Questionnaire including 25 items with a "yes/no/maybe" answer possibility
• quality of the perceived balance, assessed by the French version of the Dizziness Handicap Inventory (DHI) — Three years after gamma knife radiosurgery
  Questionnaire including 25 items with a "yes/no/maybe" answer possibility

Trial sites (1)

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