Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With Tinnitus

Condition(s) studied

Investigational drug(s) / intervention(s)

acoustics tests, Questionaries,: acoustics tests at V1 Questionaries at V1 * cognitive * emotional * auditory

MRI: Anatomical and functional MRI at V2

Study summary

the investigators have recently shown that patients with drug-resistant temporal lobe epilepsy who have undergone brain surgery targeting the medial temporal lobe structures were more likely to develop tinnitus postoperatively. This discovery of a vulnerability to tinnitus associated with medial temporal lobe surgery to eliminate drug-refractory epileptic seizures provides a new clinical model of tinnitus, targeting temporal lobe regions as generators or mediators of this hearing disorder. The objective of this project is to study the impact of tinnitus on the cognitive, emotional, psychoacoustic and cerebral functioning associated with this hearing disorder, and to clarify the pathophysiology of tinnitus by comparing different groups of individuals with tinnitus (surgical epileptic patients or non-surgical ORL patients) to matched tinnitus-free groups (surgical tinnitus-free cases and healthy controls volunteer).

Eligibility

Primary outcome measure(s)

• Evaluation of the impact of tinnitus on executive cognitive functioning — at the second visit, maximum 6 month after first visit.
  Measurement of executive control using a stroop test in people with and without chronic tinnitus.

Trial sites (2)

More Assistance Publique - Hôpitaux de Paris trials in France

Other trials for the same condition