Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA)

Condition(s) studied

Investigational drug(s) / intervention(s)

diagnostic tes for neuropathic pain: Thermotest and hot water, cold water (for the oral cavity), Von frey filament and the brush

Study summary

Following preliminary studies carried out in our department on these subject and subjective findings during clinical examinations, it has been shown that pain is a symptom that is rarely reported following treatment. Instead, neurosensory disorders such as hypoesthesia and paresthesia are found.

The objective of the study is to map and qualitatively evaluate neurosensory disorders in patients treated for cancers of the oral cavity and oropharynx.

Eligibility

Primary outcome measure(s)

• hypoesthesia on surgical site using a brush and Von Frey Filament — day 0
  The measure is a binary measure (positive or negative)
• anaesthesia on surgical site using a brush and Von Frey Filament — day 0
  The measure is a binary measure (positive or negative)
• allodynia on surgical site — day 0
  The measure is a binary measure (positive or negative) by clinical examination
• Evaluation of the characteristics of the pain by questionnaire DN4 — Day 0
  One standard DN4 with four questions and ten pain characteristics which gave a score from zero to ten points. If DN4 equal or superior of four out of ten the patient seems possible to develop neuropathic pain.
• hyperalgesia on surgical site using a brush and Von Frey Filament — Day 0
  The measure is a binary measure (positive or negative)
• Evaluation of the characteristics of the pain by questionnaire Neuropathic Pain Symptom Inventory (NPSI) — Day 0
  Twelve questions with a score from zero to ten, zero stands for no pain and ten maximal pain scale. A score is given for burning pain (score out of ten), constriction pain (score out of ten), paroxystic pain (score out of ten), evoked pain (score out of ten), paresthesia (score out of ten) and a total score (out of one hundred)
• Evaluation of the characteristics of the pain by questionnaire Brief Pain Inventory — Day 0
  Fifteen questions compose the questionnaire, the first one is a binary answer yes or no, the second one is a schema to localize the pain, thirteen following questions are scaled with a score from zero to ten, zero stands for no pain and ten maximal pain scale

Trial sites (1)

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