Signature of microRNA for patients with bethesda classification 3, 4 or 5
Signature of microRNA for patients with bethesda classification 3, 4 or 5: If the cytology results are Bethesda 3, 4 or 5, then a miRNA analysis will be performed.
Study summary
The aim is to validate a signature of microRNA (micro Ribonucleic acid) based in a first exploratory study allowing the stratification of the cytologies of indeterminate type and to study and select others. In a first step, the teams will focus on standardising the pre-analytical stages and defining a threshold of positivity. The results of microRNA signature on a cohort of 70 patients will be compared with the ultrasound and then histological data of the resection specimen.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Man or woman whose Age is ≥ 18 years
2. Patient requiring ultrasound for thyroid nodule scanning with established indication of FNAC
3. Patient with Bethesda 3, 4 and 5 thyroid nodule
4. Informed patient and signed informed consent received
5. Patient affiliated to a French medical coverage system
Exclusion Criteria:
1. Patient under guardianship, curatorship or safeguarding of justice
2. Patient whose medical or psychological conditions do not permit them to complete the study or to sign the consent,
3. Patient with metastatic cancer distinct from thyroid cancer
4. Patient who has stopped treatment (chemotherapy / immunotherapy) for cancer for less than 6 months.
Primary outcome measure(s)
Area under receiver operating characteristic (ROC) curve of the microRNA signature — 24 months
Trial sites (3)
Facility
City
Region
Status
CHU de Toulouse
Toulouse
Haute-Garonne
Institut régional du Cancer de Montpellier
Montpellier
Hérault
CHU de Nîmes
Nîmes
France
More Institut du Cancer de Montpellier - Val d'Aurelle trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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