Effects of Variation of Sodium Dialysate in ICU

Condition(s) studied

Investigational drug(s) / intervention(s)

Lowering sodium concentration dialysate: Concentration of sodium in dialysate at 140 mmol/l

Highing sodium concentration dialysate: Concentration of sodium in dialysate at 145 mmol/l

Study summary

Intermittent hemodialysis/diafiltration is a current renal replacement therapy (RRT) institued for ICU patients with AKI. For a better clinical tolerance, iinternational guidelines advise to use cold dialysate, increase duration session, decrease blood and dialysate flows, and increase level of sodium dialysate concentration (≥ 145mmol/l). Indeed, the use of a Na concentration dialysate \> 145 mmol/l improves intradialytic hemodynamic tolerance but it may also induce fluid overload by the transfert of sodium from the dialysate compartment to the blood. Yet, fluid overload has been strongly associated with mortality in critically ills. The investigators hypothesized that the use of a level in sodium dialysate at 140 mmol/l with slow low efficiency daily dialysis-filtration (SLEDD-f) will permit a fair intradialytic hemodynamic tolerance without the adverse effect of intradiaclytic Na loading from the dialysate. Two randomized groups of ICU AKI patients treated by SLEDD-f will be compared in terms of intradialytic hemodynamic tolerance and overload accordong to 140 or 145 mmol/l of Na in the dialysate

Eligibility

Primary outcome measure(s)

• Fluid overload — 7 days after the initiation of renal replacement therapy
  Daily weight measure from the initiation to the weaning of RRT. Daily monitoring of inpout and output.
• Fluid overload — day 28
  Daily weight measure from the initiation to the weaning of RRT.

Trial sites (1)

More University Hospital, Montpellier trials in France

Other trials for the same condition