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Clinical Trials in France / NCT00759304
Active, not recruiting Observational

Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events

NCT00759304 · tracked via the Priya Life Science France tracker
Sponsor
Centre Hospitalier Universitaire de Saint Etienne
Phase
Observational
Started
2000-01-02
Last updated
2025-04-29

Condition(s) studied

Healthy

Study summary

The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity.

Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population.

This PROOF study was hence designed to evaluate ANS activity levels among a healthy retired population, but should these levels decline overtime, to use this as a predictor of cardiovascular and cerebrovascular events, taking into account established cardiovascular risk factors.

Eligibility

Sex
ALL
Min age
65 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: * 65 years old * informed consent signed Exclusion Criteria: * prior myocardiac infarction * prior stroke * hearth failure * atrial fibrillation * insulin-treated diabetes mellitus * cardiac pacemaker * disease limiting life expectancy to \< 5 years * contraindication to brain MRI * living in an institution

Primary outcome measure(s)

  • Composite criterion : fatal and non-fatal cardiovascular or cerebrovascular events — During all the study

Trial sites (1)

FacilityCityRegionStatus
Centre Hospitalier de Saint-Etienne Saint-Etienne France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT00759304 on ClinicalTrials.gov ↗ ← All trials in France