Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population

NCT00741728 · tracked via the Priya Life Science France tracker

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Phase

Observational

Started

2008-05-13

Last updated

2026-02-11

Condition(s) studied

Community Based StudyCardiovascular DiseaseSudden DeathBlood Pressure

Investigational drug(s) / intervention(s)

Spider flash ECG, high-precision carotid echo-tracking, step test

Spider flash ECG, high-precision carotid echo-tracking, step test: cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes

Study summary

The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

Eligibility

Sex

ALL

Min age

50 Years

Max age

75 Years

Healthy volunteers

Accepted

Inclusion Criteria: * 50-75 years, French speaking, given consent for genetic analysis, * written consent for participating in the study Exclusion Criteria: * \<50 years and \>75 years, * no French speaking, * current pregnancy, * chronic severe disease, * disagreement for genetic analysis, * step test considered as non possible or non advisable by medical decision.

Primary outcome measure(s)

cardiovascular disease (CVD) — through study completion, an average of 24 years
incident coronary heart disease (CHD), stroke, sudden death, mortality

Trial sites (1)

Facility	City	Region	Status
Investigations Pré cliniques et Preventives de Paris	Paris	France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT00741728 on ClinicalTrials.gov ↗ ← All trials in France