Exposed/non exposed - Epidemiology: visit of daycares and environmental measurement will be performed
Study summary
CRESPI - RESPIratory health of Children in daycare
The CRESPI study, will be a cohort of 1500/2000 children attending daycare in Paris region, and will be initiated in November 2019.
The aim of the project is to study the impact of environmental exposures to cleaning products and disinfectants on respiratory health of infants and toddlers (\< 3 years) in daycares
Two specific aims were defined:
1. evaluate environmental exposure to cleaning products by complementary and innovative tools: air quality measurements in daycares, specific standardized questionnaire, identification of compounds of the products via a database and a Smartphone application to scan bar codes and inform on product use
2. evaluate the impact of early exposure in daycares and at home on respiratory health of young children
Eligibility
Sex
ALL
Min age
2 Months
Max age
4 Years
Healthy volunteers
Accepted
Inclusion Criteria:
Children :
* aged from 2 months to 3 years (\< 4 years) attending daycares in Paris region, among those which accepted to participate to the CRESPI study
* signed and dated written informed consent form obtained from at least one parent
Nursery workers :
* all those who accepted to participate
* signed and dated written informed consent form obtained
Exclusion Criteria:
Children and workers : if it is impossible for them (parents or workers) to understand French langage and/or to follow the questionnaire of the study
Children
* both parents less than 18 years old
* parents subjected to a legal protection measure or deprived of liberty by judicial or administrative decision
* if at least two children of the same familly attended the same daycare, only the youngest one will be included. In case of twins or triplets, only one children will be chosen at random.
Primary outcome measure(s)
Current wheezing — at inclusion (2019-2021) 'Current wheezing' phenotypes will be defined by questionnaires (paper, smartphone, web), based on responses to epidemiological standardized questionnaires and in accordance with definitions used in international studies:
* wheezing in the last 12 months
* severe wheezing in the last 12 months (defined by wheezing in the last 12 months with use of inhaled corticosteroid and/or the need for hospital-based care \[emergency department visit and/or hospitalization due to bronchiolitis wheezy bronchitis or asthma attacks\] in the last 12 months)
* recurrent wheezing (at least 3 wheezing episodes in the last 12 months).
Longitudinal wheezing — at inclusion (2019-2021), every month by a smartphone application (during 1 year after inclusion), every 6 months by questionnaires (2021 to 2023) Longitudinal wheezing phenotypes will be defined by longitudinal latent class analysis (statistical clustering approach), making full use of data collected by questionnaire during follow-up (first monthly and then every six months), from infancy to age 4-years.
Trial sites (1)
Facility
City
Region
Status
Nicole LE MOUAL
Villejuif
France
More Institut National de la Santé Et de la Recherche Médicale, France trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.
