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Clinical Trials in Egypt / NCT07867067
Starting soon Phase 2

Effect of Gingival Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Management of Infra-bony Periodontal Defect

NCT07867067 · tracked via the Priya Life Science Egypt tracker
Sponsor
Ain Shams University
Phase
Phase 2
Started
2026-10-01
Last updated
2026-10-15

Condition(s) studied

Infra-bony Periodontal Defect

Investigational drug(s) / intervention(s)

Gingival mesenchymal stem cell derived small extracellular vesiclesβ-calcium triphosphate (β-TCP) + collagen membrane

Gingival mesenchymal stem cell derived small extracellular vesicles: gingival sample will be taken from the patient and cultured for small extracellular vesicles extraction and then will be carried on a B-TCP scaffold covered by collagen membrane inserted into infra-bony periodontal defect in the same patient for arm group 1

β-calcium triphosphate (β-TCP) + collagen membrane: in patients with infra-bony periodontal pockets will be received beta tricalcium phosphate scaffold covered by collagen membrane as a control group

Study summary

The goal of the study to evaluate whether the adjunctive use of gingival mesenchymal stem cell-derived extracellular vesicles (GMSC-derived EVs) combined with β-tricalcium phosphate (β-TCP) and a collagen membrane results in superior radiographic bone fill compared to β-TCP and collagen membrane alone in the surgical management of infra-bony periodontal defects over a 6-month follow-up period.

Eligibility

Sex
ALL
Min age
20 Years
Max age
40 Years
Healthy volunteers
No
Inclusion Criteria * Healthy Individuals * Non-smokers * Presence of interproximal defect in the bone wall of two or three osseous estimated by periapical radiographic evaluation and probing depth ≥6 mm after S1 and S2 therapy * Loss of clinical attachment ≥4 mm after S1 and S2 treatment * Full mouth plaque score and bleeding on probing score ≤20% after S1 and S2 therapy * Only vital teeth involved * Thick gingival biotype more than 1 mm with enough width of attached gingiva. * Exclusion Criteria: * Pregnant and lactating females. * Non-cooperating patients. Individuals with decision problems (prisoners, disabled, and mentally retarded patients)

Primary outcome measure(s)

  • bone fill/gain — 6 months
    by paralleling periapical technique, evaluate amount of bone fill

Trial sites (1)

FacilityCityRegionStatus
Faculty of Dentistry Ain Shams University Cairo Egypt

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07867067 on ClinicalTrials.gov ↗ ← All trials in Egypt