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Clinical Trials in Egypt / NCT07855367
Recruiting Not applicable

Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis

NCT07855367 · tracked via the Priya Life Science Egypt tracker
Sponsor
National Cancer Institute, Egypt
Phase
Not applicable
Started
2026-09-15
Last updated
2026-10-02

Condition(s) studied

CryoneurolysisBipolar Radiofrequency AblationGenicular NervesPain ReliefSymptomaticKnee Osteoarthritis

Investigational drug(s) / intervention(s)

Ultrasound-guided cryoneurolysisBipolar radiofrequency ablation

Ultrasound-guided cryoneurolysis: Patients will undergo ultrasound-guided cryoneurolysis

Bipolar radiofrequency ablation: Patients will undergo bipolar radiofrequency ablation

Study summary

This study aims to compare the reduction in knee pain between ultrasound-guided cryoneurolysis and bipolar radiofrequency ablation (RFA), as measured by the Numerical Rating Scale (NRS) at predefined follow-up intervals.

Eligibility

Sex
ALL
Min age
40 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥ 40 years * Symptomatic knee osteoarthritis (OA) in bladder cancer patient \[based on American College of Radiology (ACR) criteria\] * Radiological OA (Kellgren-Lawrence grade III-IV) * Chronic knee pain ≥ 3-6 months * Numerical Rating Scale (NRS) ≥ 5 despite conservative treatment * Positive diagnostic genicular nerve block (\>50% pain relief). Exclusion Criteria: * Prior genicular nerve ablation * Coagulopathy * Local infection * Severe deformity * Neuropathic pain syndromes * Uncontrolled comorbidities

Primary outcome measure(s)

  • Degree of pain — 6 months after procedure
    Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS) score. NRS (0 represents "no pain" while 10 represents "the worst pain imaginable").

Trial sites (1)

FacilityCityRegionStatus
Cairo University Cairo Egypt Recruiting

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Other trials for the same condition

Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoarthritis Patients Starting soon
Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis Recruiting
Early Weight Bearing After Open Wedge High Tibial Osteotomy (OWHTO), Is it Worth? Active, not recruiting
Novel Transdermal Ketoprofen Gel Formulation for Knee Osteoarthritis Active, not recruiting
Reflexology and Mulligan Mobilization for Knee Osteoarthritis Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07855367 on ClinicalTrials.gov ↗ ← All trials in Egypt