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Clinical Trials in Egypt / NCT07823556
Active, not recruiting Not applicable

The Role of Transforming Growth Factor- Beta (TGF- β) Expression in Renal Biopsy of Lupus Nephritis Patients

NCT07823556 · tracked via the Priya Life Science Egypt tracker
Sponsor
Ain Shams University
Phase
Not applicable
Started
2026-05-31
Last updated
2026-09-16

Condition(s) studied

Lupus Nephritis (LN)

Investigational drug(s) / intervention(s)

renal biopsy

renal biopsy: Kidney fibrosis will be assessed by means of needle core biopsy followed by histopathological assessment. Percutaneous kidney biopsies will be performed with ultrasonic guidance under local anaesthesia by an expert nephrologist.

Study summary

To investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices

Eligibility

Sex
ALL
Min age
18 Years
Max age
50 Years
Healthy volunteers
No
Inclusion Criteria: * SLE patients who fulfilled EULAR/ACR 2019 Classification Criteria for Systemic Lupus Erythematosus , having lupus nephritis. * Adult population with age group from 18 to 50 years old. Exclusion Criteria: * Patients with any other Rheumatological diseases such as other autoimmune CT diseases or vasculitides * Pregnancy. * Ongoing or previous chemotherapy treatment for cancer. * Any other causes of CKD or AKI ( acute kidney injury).

Primary outcome measure(s)

  • renal biopsy — 12 months
    to test for the presence of Transforming Growth Factor- Beta (TGF- β) in renal biopsy of patients with lupus nephritis. All renal biopsies will be evaluated according to NIH activity and chronicity indices and fibrosis quantification according to IFTA score.

Trial sites (1)

FacilityCityRegionStatus
Ain Shams University Cairo Egypt

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Other trials for the same condition

The Efficacy of Empagliflozin on Kidney Functions in Lupus Nephritis Population Recruiting
Non Invasive Assessment of Subclinical Atherosclerosis and Cardiovascular Risk Using TYG Index in Lupus Nephritis Starting soon
Urinary Congophilia as an Indicator of Activity of Lupus Nephritis Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07823556 on ClinicalTrials.gov ↗ ← All trials in Egypt