Comparison Low-volume Versus Standard-volume Ultrasound-guided Bilateral Intermediate Cervical Plexus Block

NCT07789548 · tracked via the Priya Life Science Egypt tracker

Sponsor

Assiut University

Phase

Phase 4

Started

2026-09-01

Last updated

2026-09-01

Condition(s) studied

Post Operative Pain Relief After Thyroidectomy

Investigational drug(s) / intervention(s)

Bupivacain onlyBupivacain only

Bupivacain only: Bilateral intermediate cervical plexus block using ultrasound-guided bupivacaine 0.5% for low volume group

Bupivacain only: Bilateral intermediate cervical plexus block using ultrasound-guided bupivacaine 0.25% for standard group

Study summary

Thyroidectomy is commonly associated with mild-to-moderate postoperative pain that may affect respiratory function and recovery. Bilateral intermediate cervical plexus block provides effective analgesia, but larger local anesthetic volumes may increase phrenic nerve spread and diaphragmatic dysfunction. Low-volume ultrasound-guided block may provide adequate analgesia while better preserving diaphragmatic function and postoperative respiratory performance

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Adult patients aged between 18 and 65 years. * Patients scheduled for elective thyroidectomy under general anesthesia. * American Society of Anesthesiologists (ASA) physical status I-II. * Both sexes will be included. * Patients able to understand the study protocol and provide written informed consent. Exclusion Criteria: * Patient refusal. * Other endocrine diseases (as uncontrolled diabetes mellitus, adrenal disorders, pituitary disorders) * Known allergy or hypersensitivity to local anesthetics. * Coagulopathy or ongoing anticoagulant therapy contraindicating regional anesthesia. * Local infection at the site of needle insertion. * Preexisting diaphragmatic dysfunction or phrenic nerve palsy. * Significant chronic respiratory disease affecting pulmonary function (e.g., severe COPD, restrictive lung disease, uncontrolled asthma). * Morbid obesity (BMI ≥ 35 kg/m²). * Psychiatric or neurological diseases affecting respiratory muscles. * Previous neck surgery or anatomical deformity interfering with cervical plexus --block performance or diaphragmatic ultrasound assessment. * Pregnancy..

Primary outcome measure(s)

Change in diaphragmatic excursion in patient undergoing thyroidectomy — Baseline before block, 30 minutes after block.4 hour after block
Ultrasound-measured diaphragmatic excursion (cm), assessed at baseline before block and at predefined postoperative time points, to compare the effect of low-volume versus standard-volume bilateral intermediate cervical plexus block on diaphragmatic function.

Trial sites (1)

Facility	City	Region	Status
Assiut main university hospital	Asyut	Egypt	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07789548 on ClinicalTrials.gov ↗ ← All trials in Egypt