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Surgical Outcomes of Extended Endoscopic Endonasal Approach for Skull Base Lesions.

NCT07788300 · tracked via the Priya Life Science Egypt tracker
Phase
Not applicable
Started
2026-09-01
Last updated
2026-08-26

Condition(s) studied

Skull Base Neoplasms

Investigational drug(s) / intervention(s)

Endoscopic Endonasal Approach for Skull Base Lesions.

Endoscopic Endonasal Approach for Skull Base Lesions.: Surgical Outcomes of Extended Endoscopic Endonasal Approach for Skull Base Lesions

Study summary

Aim of this study is to evaluate the surgical and functional outcomes of the extended endoscopic endonasal approach (EEEA) in the management of skull base lesions, including extent of resection, postoperative complications, and clinical outcomes.

Eligibility

Sex
ALL
Min age
16 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * 1\. Adult patients aged 18 years or older. 2. Patients with radiologically confirmed skull base lesions (based on MRI ± CT) involving the anterior, middle, or posterior skull base. 3\. Patients undergoing lesion resection using the extended endoscopic endonasal approach (EEEA). 4\. Lesions amenable to endoscopic endonasal access, including: Pituitary adenomas with extrasellar extension Craniopharyngiomas Skull base meningiomas Chordomas and other midline skull base lesions 5. Availability of complete preoperative assessment, including: Clinical evaluation Neuro-ophthalmological assessment (when applicable) Radiological imaging 6. Availability of detailed intraoperative data, including surgical approach and intraoperative findings. 7\. Availability of early postoperative MRI (within 72 hours to 3 months) to assess the extent of resection. 8\. Patients with adequate postoperative follow-up (minimum 3 months) for evaluation of outcomes and complications. Exclusion Criteria: * 1\. Patients aged less than 18 years. 2. Patients who underwent transcranial approaches. 3. Lesions not primarily involving the skull base or not suitable for endoscopic endonasal access. 4\. Patients with incomplete clinical, radiological, or operative data. 5. Absence of early postoperative MRI, making assessment of the extent of resection unreliable. 6\. Patients with insufficient follow-up (less than 3 months). 7. Cases managed by biopsy only without attempted lesion resection. 8. Patients with severe comorbidities significantly affecting surgical outcome (e.g., advanced systemic disease), if they introduce bias in outcome assessment.

Primary outcome measure(s)

  • Extent of lesion resection — 2 years
    Extent of lesion resection (Gross total resection vs Subtotal resection) based on postoperative MRI

Trial sites (1)

FacilityCityRegionStatus
Assiut university Asyut Egypt
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07788300 on ClinicalTrials.gov ↗ ← All trials in Egypt