Combined Fractional CO₂ Laser and Topical Corticosteroid Versus Topical Corticosteroid Only in the Treatment of Palmoplantar Psoriasis

NCT07713212 · tracked via the Priya Life Science Egypt tracker

Sponsor

Cairo University

Phase

Phase 4

Started

2026-08-15

Last updated

2026-07-20

Condition(s) studied

Psoriasis

Investigational drug(s) / intervention(s)

Fractional CO2 laser assisted drug deliveryTopical Corticosteroid (TCS)

Fractional CO2 laser assisted drug delivery: Sessions of fractional CO2 every 4 weeks with application of topical steroids

Topical Corticosteroid (TCS): Daily application of topical corticosteroids on palmoplantar psoriasis

Study summary

To assess whether adding fractional laser to topical corticosteroid improves treatment outcomes in palmoplanter psoriasis compared to topical corticosteroid alone.

Eligibility

Sex

ALL

Min age

18 Years

Max age

60 Years

Healthy volunteers

Inclusion criteria * Adults aged ≥18 years * Stable psoriasis * Confirmed cases of palmoplantar psoriasis (with or without psoriasis elsewhere) dermoscopically(Hand \_held dermoscopy) and histopathologically if required. * Willingness to comply with treatment and follow-up * Written informed consent obtained Exclusion criteria: * Other palmoplantar dermatoses (eczema, tinea, keratoderma) * Generlized Pustular psoriasis * Erythrodermic psoriasis * Use of: * Systemic antipsoriatic therapy within 3 months * Biologic therapy within 12 weeks * Topical treatment on palms/soles within 2 weeks * Pregnancy or lactation * History of photosensitivity disorders

Primary outcome measure(s)

Improvement in Palmoplantar Psoriasis Severity Index (ppPASI) by topical corticosteroids only vs fractional CO₂ laser-assisted delivery of topical corticosteroids — 3 month
The primary outcome will be the change in the Palmoplantar Psoriasis Severity Index (ppPASI) score from baseline to the end of treatment (at Week 12). The ppPASI assesses disease severity based on erythema, scaling, and induration/infiltration of the palms and soles, in addition to the affected surface area. Scores range from 0 to 72, with higher scores indicating more severe disease. Treatment success: Achievement of ppPASI-50, ppPASI-75, and ppPASI-90 (≥50%, ≥75%, and ≥90% reduction from baseline).

Trial sites (1)

Facility	City	Region	Status
Cairo University	Cairo	Cairo Governorate

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07713212 on ClinicalTrials.gov ↗ ← All trials in Egypt