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Clinical Trials in Egypt / NCT07709182
Recruiting Not applicable

Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients

NCT07709182 · tracked via the Priya Life Science Egypt tracker
Sponsor
Tanta University
Phase
Not applicable
Started
2026-02-01
Last updated
2026-07-16

Condition(s) studied

Airway Occlusion PressurePressure Support VentilationConventional ManagementWeaning Window Patients

Investigational drug(s) / intervention(s)

Pressure support ventilation protocolAirway occlusion pressure (P0.1)-guided pressure support ventilation (PSV)

Pressure support ventilation protocol: Patients will receive a conventional pressure support ventilation protocol.

Airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV): Patients will receive airway occlusion pressure (P0.1)-guided pressure support ventilation (PSV).

Study summary

This study aims to determine whether Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation is superior to conventional management for patients in weaning windows.

Eligibility

Sex
ALL
Min age
21 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Mechanically ventilated adult patients ≥ 21 years. * Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status. * Hemodynamically stable \[mean arterial pressure (MAP) ≥60 mmHg\]. * All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive. Exclusion Criteria: * Patients with neuromuscular disorders affecting respiratory drive * Glasgow Coma Scale (GCS) score below 8 * Cervical spinal cord injury * Receipt of neuromuscular blockers within the previous 24 hours * Morbid obesity resulting in unreliable respiratory mechanics * Pregnancy * Deep sedation defined as RASS ≤ -2 * Hemodynamic instability requiring escalating vasopressor support.

Primary outcome measure(s)

  • Ventilator-Free Days — Day 28 after the procedure
    Ventilator-Free Days (VFD) at Day 28, defined as the number of days a patient is free from mechanical ventilation within the first 28 days after randomization. VFD are calculated as 28 minus the total days on mechanical ventilation from Day 0 until successful extubation.

Trial sites (1)

FacilityCityRegionStatus
Tanta University Tanta Al Gharbia Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07709182 on ClinicalTrials.gov ↗ ← All trials in Egypt