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Clinical Trials in Egypt / NCT07624019
Recruiting Observational

Renal SWE as a Predictor After Pediatric Pyeloplasty for UPJO

NCT07624019 · tracked via the Priya Life Science Egypt tracker
Sponsor
Beni-Suef University
Phase
Observational
Started
2026-05-06
Last updated
2026-06-03

Condition(s) studied

Ureteropelvic Junction ObstructionRenal Functional Recovery

Study summary

Ureteropelvic junction obstruction is an important cause of hydronephrosis and potentially reversible renal functional impairment in children. Although open pyeloplasty is an effective standard treatment, the degree of postoperative renal functional recovery varies between patients.

This prospective observational cohort study will evaluate whether renal cortical shear wave elastography can predict renal functional recovery after open pyeloplasty in children with unilateral primary ureteropelvic junction obstruction. Renal cortical shear wave elastography will be assessed before surgery and during follow-up, and the change in elastography values will be compared with renal isotope findings after surgery.

The primary objective is to evaluate the predictive value of the change in renal cortical shear wave elastography from baseline to 3 months after surgery for isotope-defined renal functional recovery at 6 months after open pyeloplasty.

Eligibility

Sex
ALL
Min age
6 Months
Max age
18 Years
Healthy volunteers
No
Inclusion Criteria: * Children aged 6 months to 18 years. * Diagnosis of unilateral primary ureteropelvic junction obstruction. * Planned for open dismembered pyeloplasty. * Availability of preoperative renal ultrasonography, renal cortical shear wave elastography, and diuretic renography. * Written informed consent obtained from parent or legal guardian. Exclusion Criteria: * Bilateral ureteropelvic junction obstruction. * Secondary ureteropelvic junction obstruction. * Previous ipsilateral upper urinary tract surgery. * Associated major urinary tract anomalies likely to independently affect renal function, including vesicoureteral reflux, megaureter, duplex system, posterior urethral valves, or ectopic kidney. * Active urinary tract infection at the time of assessment. * Known intrinsic renal parenchymal disease unrelated to obstruction. * Inability to obtain reliable shear wave elastography measurements. * Incomplete planned follow-up.

Primary outcome measure(s)

  • Predictive Accuracy of 3-Month Change in Renal Cortical SWE for 6-Month Functional Recovery — Baseline to 6 months after open pyeloplasty
    The change in renal cortical shear wave elastography from baseline to 3 months after open pyeloplasty will be evaluated for its ability to predict renal functional recovery at 6 months.

Trial sites (1)

FacilityCityRegionStatus
Department of Urology- Beni-Suef University Hospitals Banī Suwayf Beni Suweif Governorate Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07624019 on ClinicalTrials.gov ↗ ← All trials in Egypt