Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis

Condition(s) studied

Investigational drug(s) / intervention(s)

cardiac troponin, and blood culture: D) Echocardiographic examination: will be done according to the recommendation of the American Society of Echocardiography Integrated M-mode, two-dimensional (2-D) mode and pulsed and continuous wave Doppler will be used to estimate left ventricle (LV) internal dimensions including LV end diastolic dimension, LV ventricle end systolic dimension, ventricular septal thickness, posterior wall thickness, fractional shortening, mitral and tricuspid inflow velocities, and systolic pulmonary artery pressure. From the apical four-chamber planes, using pulsed wave tissue Doppler, the myocardial velocity curves of septal mitral valve annulus, lateral mitral valve annulus, and lateral tricuspid valve annulus will be recorded. The systolic wave (S) reflects the systolic function of either right or left ventricle. The early/atrial (E'/A') ratio of tricuspid and mitral valve annulus reflects the diastolic function of the right and left ventricle, respectively.

Study summary

1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography.
2. To assess sepsis induced cardiac dysfunction.
3. To measure serum levels of sepsis markers (CBC,CRP,Blood culture) and cardiac troponin in neonatal sepsis.
4. To analyze the correlation between echocardiographic parameters and serum biomarkers.
5. To determine whether these echocardiographic techniques can serve as early predictors of cardiac involvement in neonatal sepsis.

Eligibility

Primary outcome measure(s)

• assess myocardial function in neonates with sepsis using tissue doppler echocardiography. — 1 year
  To analyze the correlation between echocardiographic parameters and serum biomarkers.

Trial sites (1)

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