Portal Vein Thrombosis in Liver Cirrhosis: Clinical Characteristics, Radiological Patterns, and Predictors

Condition(s) studied

Investigational drug(s) / intervention(s)

Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed: to assess portal circulation, portosystemic collaterals, the presence of PVT, ascites and HCC.

Study summary

Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis and is associated with increased morbidity due to worsening portal hypertension and hepatic decompensation. The clinical presentation and radiological patterns of PVT vary widely, and the factors predicting its development remain incompletely understood.

This observational study will include adult patients (≥18 years) with established liver cirrhosis who are admitted to the Department of Gastroenterology and Tropical Medicine, Al-Rajhi Liver Hospital, Assiut University. Eligible participants will undergo routine screening for PVT using Doppler ultrasonography, with confirmation by contrast-enhanced computed tomography when indicated.

The study aims to evaluate the clinical characteristics, laboratory parameters, and radiological features of PVT. Cases of PVT will be classified according to extent (partial or complete) and anatomical location (main portal vein, right branch, left branch, or combined involvement). Clinical and laboratory data will be analyzed to identify potential predictors associated with the development and severity of PVT.

The findings of this study are expected to improve understanding of the risk factors and radiological patterns of PVT in cirrhotic patients, contributing to better risk stratification and clinical management.

Eligibility

Primary outcome measure(s)

• Prevalence of Portal Vein Thrombosis (PVT) — At baseline (during study enrollment period)
  Proportion of cirrhotic patients diagnosed with portal vein thrombosis based on Doppler ultrasonography with confirmation by contrast-enhanced CT when indicated.
• Predictors of Portal Vein Thrombosis — Baseline assessment
  Identification of clinical, laboratory, and radiological factors associated with the presence of PVT in cirrhotic patients

Trial sites (1)

Other trials for the same condition