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Clinical Trials in Egypt / NCT07557329
Starting soon Observational

Intestinal Endotoxemia and Beta- Cell Dysfunction in Prediabetics

NCT07557329 · tracked via the Priya Life Science Egypt tracker
Sponsor
Sohag University
Phase
Observational
Started
2026-05
Last updated
2026-05-05

Condition(s) studied

Prediabetic State (IGT)Prediabetic State

Investigational drug(s) / intervention(s)

hba1c, lbp, fasting blood sugar, lipogram, fastinf insulin

hba1c, lbp, fasting blood sugar, lipogram, fastinf insulin: diagnostic tests for prediabetes and intestinal endotoxemia

Study summary

the goal of this observation study is to learn about association between intestinal endotoxemia and prediabetes lean patients with the aim of prevention of diabetes in those category of patients

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: * Age: 18-65 years * BMI: 18.5-24.9 kg/m² * ADA prediabetes: FPG 100-125 mg/dL OR 2hPG 140-199 mg/dL OR HbA1c 5.7-6.4% * HOMA-IR \<1.5 (key inclusion criterion) Exclusion Criteria: * \- HOMA-IR ≥1.5 * BMI ≥25 kg/m² * Diabetes, acute inflammation, GI disorders (Table 1) Group II (Controls): Lean normoglycemic ; age and sex-matched healthy subjects

Primary outcome measure(s)

  • correlation between intestinal endotoxemia (measured by serum LBP) and basal beta-cell dysfunction (HOMA-B) in lean prediabetic patients — one year
    To determine the correlation between intestinal endotoxemia (measured by serum LBP) and basal beta-cell dysfunction (HOMA-B) in lean prediabetic patients with minimal insulin resistance (HOMA-IR \<1.5).

Trial sites (1)

FacilityCityRegionStatus
Sohag University Sohag Egypt

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07557329 on ClinicalTrials.gov ↗ ← All trials in Egypt