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Clinical Trials in Egypt / NCT07515456
Recruiting Not applicable

Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache

NCT07515456 · tracked via the Priya Life Science Egypt tracker
Sponsor
Tanta University
Phase
Not applicable
Started
2024-12-01
Last updated
2026-04-07

Condition(s) studied

TheophyllineSumatriptanGabapentinPost-Dural Puncture Headache

Investigational drug(s) / intervention(s)

Theophylline →Sumatriptan →Gabapentin →

Theophylline: Patients included in this group will receive oral 150 mg theophylline anhydrous tablet (QuibronT/SR, 300 mg dividose tablet, SmithKline Beecham Egypt L.L.C) every 12 hours.

Sumatriptan: Patients included in this group will receive oral 25 mg sumatriptan succinate tablet (Sumigran 25, 25 mg tablet, Sigma pharmaceutical industries, Egypt) every 12 hours.

Gabapentin: Patients included in this group will receive 200 mg of gabapentin every 12 hours.

Study summary

The aim of this study is to compare the safety and efficacy of theophylline, sumatriptan, and gabapentin in the treatment of post-dural puncture headache.

Eligibility

Sex
ALL
Min age
21 Years
Max age
50 Years
Healthy volunteers
No
Inclusion Criteria: * Age from 21 to 50 years. * Both sexes. * American Society of Anesthesiologists (ASA) physical status ≤ II. * Patient's selection for this study will be based on clinical diagnosis suggesting post-dural puncture headache (PDPH) based on the International Headache Society criteria. * Patients with numeric rating scale (NRS) of ≥ 5. Exclusion Criteria: * Pregnant women. * History of; chronic headache, cluster headache, migraine, convulsions, cerebrovascular accident, and previous neurological diseases. * Signs of meningismus. * Dysrhythmia. * Hypertension. * Ischemic heart disease. * Hyperthyroidism. * Peripheral vascular disease (ischemic colitis). * Liver or renal impairment. * Use of selective serotonin reuptake inhibitors. * Use of ergotamine derivatives in the past 24 hours. * Use of monoamine oxidase inhibitors in the last 2 weeks. * Use of any kind of opiates. * Allergy to the study medications and any contraindication of oral intake.

Primary outcome measure(s)

  • Severity of headache — 24 hours after drug treatment.
    Severity of headache will be assessed using numeric rating scale (NRS) score where 0 = no pain, and 10 = worst possible pain.

Trial sites (1)

FacilityCityRegionStatus
Tanta University Tanta El-Gharbia Recruiting

On this site

📄 Neurontin (gabapentin) drug profile →

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Other trials for the same condition

Comparison of Nebulized Neostigmine/Atropine Versus Lignocaine in Treating Acute Post-dural Puncture Headache Following Subarachnoid Block in Parturient Undergoing Elective Cesarean Section. A Randomized, Clinical Trial. Recruiting
Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07515456 on ClinicalTrials.gov ↗ ← All trials in Egypt