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Clinical Trials in Egypt / NCT07464808
Recruiting Not applicable

Utilizing Anti-Factor Xa as a Predictive Tool for Optimizing Outcome in Burn Patients' Management

NCT07464808 · tracked via the Priya Life Science Egypt tracker
Sponsor
Ain Shams University
Phase
Not applicable
Started
2025-11-28
Last updated
2026-03-11

Condition(s) studied

Venous Thromboembolic Event

Investigational drug(s) / intervention(s)

follow up venous thrombo embolic events with routine clexan dose modification guided by anti factor 10 assayfollow up venous thromboembolic events with no routine clexan dosage modification and no usage of anti factor 10 assay

follow up venous thrombo embolic events with routine clexan dose modification guided by anti factor 10 assay: follow up vte incidence and routine clexan dose modification

follow up venous thromboembolic events with no routine clexan dosage modification and no usage of anti factor 10 assay: follow up of vte incidence with no routine dose modification unless indicated

Study summary

This study aims to compare the efficacy of anti-Xa based versus weight-based enoxaparin dosing and to evaluate anti-Xa levels as a predictive tool for clinical outcomes in burn patients

Eligibility

Sex
ALL
Min age
21 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Adults (≥21 years) admitted to the burn unit with thermal burns ≥20% TBSA and \< 60%. 2. Admission to BICU within 48 hours of burn injury. 3. Indication for VTE prophylaxis (e.g., immobilized, surgical intervention). 4. Ability to provide informed consent Exclusion Criteria: 1. Pre-existing coagulopathy or anticoagulant therapy prior to injury. 2. Patients with severe comorbidities (e.g., end-stage renal failure, advanced malignancy, hepatic disease). 3. Need for therapeutic anticoagulant therapy. 4. patients with extremes of weight, (45kg \>=weight \>= 150kg).

Primary outcome measure(s)

  • VTE incidence — from incidence of burn injury and start of anticoagulation till 30day post burn or till discharge from ICU
    Incidence of 30-day symptomatic VTE (confirmed by Doppler ultrasound or CT angiography) in anti-Xa-guided vs. fixed-dose enoxaparin group

Trial sites (1)

FacilityCityRegionStatus
Ain Shams University Cairo Abbassia Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07464808 on ClinicalTrials.gov ↗ ← All trials in Egypt