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Clinical Trials in Egypt / NCT07427342
Starting soon Observational

Cerebral Blood Flow in Term and Preterm Neonates Using Doppler Ultrasonography

NCT07427342 · tracked via the Priya Life Science Egypt tracker
Sponsor
Assiut University
Phase
Observational
Started
2026-04-15
Last updated
2026-02-23

Condition(s) studied

Cerebral Blood Flow

Study summary

This study aims to evaluate cerebral blood flow in stable term and preterm newborns using Doppler ultrasonography. By measuring and comparing PSV, EDV, RI, and PI in the main brain arteries, the study seeks to identify normal physiological differences in cerebral perfusion across different gestational ages. The main goal is to establish reference values that can guide clinical monitoring, allow early detection of blood flow problems, and improve neuroprotective care in newborns.

Eligibility

Sex
ALL
Min age
1 Hour
Max age
48 Hours
Healthy volunteers
No
Inclusion Criteria: * Term neonates ≥ 37 weeks of gestational age. * Preterm neonates \< 37 weeks' gestational age. * Hemodynamically stable infants at the time of examination. * Parental/guardian informed consent obtained. * Within the first 48 hours after birth. * Birth weight appreciate for gestational age. Exclusion Criteria: * Infants aged more than 48 hours after birth. * Neonates with major congenital anomalies (cardiac, neurological, or craniofacial). * Suspected or confirmed intracranial hemorrhage or brain malformations, such as intraventricular hemorrhage, may influence RI measurements and interfere with accurate assessment of cerebral blood flow. * Neonates requiring inotropic support at the time of scan. * Neonates with severe respiratory instability or mechanical ventilation (unless included intentionally). * Infants with sepsis or metabolic derangements affecting cerebral perfusion.

Primary outcome measure(s)

  • Resistive Index (RI) — Baseline
    RI = (PSV - EDV)/PSV, indicates downstream resistance and the flexibility of cerebral vessels
  • Pulsatility Index (PI) — Baseline
    quantifies the shape of the blood flow waveform, reflecting how much the flow changes throughout the cardiac cycle.
  • Peak Systolic Velocity (PSV) — Baseline
    represents blood flow during systole and reflects cardiac output
  • End-Diastolic Velocity (EDV) — Baseline
    EDV reflects diastolic flow and the resistance in the vessels

Trial sites (1)

FacilityCityRegionStatus
Assiut university Asyut Egypt

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07427342 on ClinicalTrials.gov ↗ ← All trials in Egypt