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Clinical Trials in Egypt / NCT07203976
Active, not recruiting Observational

Visual and Refractive Outcomes Following Stream Light Photorefractive Keratectomy (55μm Epithelial Removal) Versus Conventional Photorefractive Keratectomy

NCT07203976 · tracked via the Priya Life Science Egypt tracker
Sponsor
Assiut University
Phase
Observational
Started
2025-05-03
Last updated
2025-10-02

Condition(s) studied

Photorefractive Keratectomy

Study summary

Photorefractive keratectomy (PRK) is a well-established corneal refractive surgery that involves epithelial removal followed by stromal ablation to correct myopia, hyperopia, and astigmatism. The method of epithelial removal in PRK significantly impacts healing, pain levels, and visual outcomes.

Trans-epithelial PRK (StreamLight) performed on the EX500 excimer laser platform removes the epithelium and reshapes the corneal stroma in a single laser-guided step, potentially reducing tissue manipulation and enhancing epithelial healing. In contrast, manual epithelial removal PRK involves mechanical debridement, with epithelial removal depth being manually controlled. The variability of epithelial thickness in StreamLight PRK may influence visual outcomes, whereas in manual PRK, a fixed epithelial removal depth of 55 microns provides a standardized approach.

Eligibility

Sex
ALL
Min age
18 Years
Max age
40 Years
Healthy volunteers
No
Inclusion Criteria: * Patients aged 18-40 years. * Myopia up to -6.00 D and astigmatism up to -3.00 D. * Stable refraction for at least one year. * No history of ocular surgery or corneal pathology. Exclusion Criteria: * Presence of keratoconus or suspected corneal ectasia. * Severe dry eye disease or significant ocular surface disease. * History of autoimmune disease or systemic conditions affecting wound healing. * Prior herpetic eye disease.

Primary outcome measure(s)

  • Post operative distant uncorrected visual acuity — 1 year
    using snellen chart

Trial sites (1)

FacilityCityRegionStatus
Faculty of medicine, Assiut Asyut Egypt

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07203976 on ClinicalTrials.gov ↗ ← All trials in Egypt