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Clinical Trials in Egypt / NCT07069933
Starting soon Phase 2

Repurposing Itraconazole as an Adjuvant Therapy in Treatment of Patients With Acute Myeloid Leukemia: Is it a Hopeful Avenue for Enhancing Treatment Options?

NCT07069933 · tracked via the Priya Life Science Egypt tracker
Sponsor
Mansoura University
Phase
Phase 2
Started
2025-07
Last updated
2025-07-17

Condition(s) studied

Acute Myeloid Leukemia

Investigational drug(s) / intervention(s)

Standard care +itraconazole 200mg →Chemotherapy

Standard care +itraconazole 200mg: Is an antifungal used to treat a variety of fungal infections. It belongs to a class of drugs known as azole antifungals.

Chemotherapy: Standard Care (in control arm)

Study summary

A prospective, randomized, controlled, parallel clinical trial will be conducted at Clinical Oncology and Nuclear Medicine Center at Mansoura University Hospital to assess the efficacy of Itraconazole as an adjuvant therapy in treatment of patients with acute myeloid Leukemia.

Eligibility

Sex
ALL
Min age
18 Years
Max age
100 Years
Healthy volunteers
Accepted
Inclusion Criteria: 1. Patients with Acute Myeloid leukemia, and aged 18 years or older 2. Patients whose ECOG performance status ranged from 0-2 and are fit for all treatments protocols Exclusion Criteria: 1. Patients with any other types of malignancies rather than Leukemia and patients. 2. Patients with history alcohol intake, acute or chronic. 3. Patients with documented hypersensitivity or allergy to Itraconazole. 4. Patients suffer from chronic heart failure 5. Patients present with severe dehydration. 6. Patients with severe kidney dysfunction

Primary outcome measure(s)

  • Percentage of blasts in bone marrow at d21 after induction — 8 weeks

Trial sites (1)

FacilityCityRegionStatus
Clinical Oncology and Nuclear Medicine of Mansoura University Hospital, Mansoura, Al Mansurah Egypt

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Other trials for the same condition

Molecular Characterization of Carbapenemase-Producing Enterobacterales Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07069933 on ClinicalTrials.gov ↗ ← All trials in Egypt